Bullous Sweet's Syndrome and Pseudolymphoma Precipitated by IL-2 Therapy

Department of Dermatology, Henry Ford Hospital, Detroit, Michigan, USA.
Cutis; cutaneous medicine for the practitioner (Impact Factor: 0.72). 04/2010; 85(4):206-13.
Source: PubMed


IL-2 is a key cytokine in cell-mediated immunity and currently is used in clinical trials as immunologic therapy in human immunodeficiency virus (HIV)-positive patients. Although cutaneous reactions to IL-2 therapy are common, bullous reactions are rare. We report a case of an HIV-positive patient who received multiple cycles of IL-2 therapy and developed a bullous eruption soon after each cycle was initiated. Pathology results from 2 separate outbreaks revealed a diffuse dermal neutrophilic infiltrate with leukocytoclasis. Epidermal spongiosis and focal intraepidermal vesiculation also were present. The patient discontinued IL-2 therapy but restarted 5 years later, at which time he presented with a pseudolymphomatous reaction that resolved after discontinuation of therapy. This patient is an unusual case of 2 different eruptions--Sweet's syndrome and pseudolymphoma-precipitated by IL-2 therapy in the same patient. Cutaneous eruptions to IL-2 therapy also are reviewed.

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