Patients With Schizophrenia Demonstrate Inconsistent Preference Judgments for Affective and Nonaffective Stimuli

Department of Psychiatry, University of Maryland School of Medicine, Baltimore,MD 21228, USA.
Schizophrenia Bulletin (Impact Factor: 8.45). 11/2011; 37(6):1295-304. DOI: 10.1093/schbul/sbq047
Source: PubMed


Previous studies have typically found that individuals with schizophrenia (SZ) report levels of emotional experience that are similar to controls (CN) when asked to view a single evocative stimulus and make an absolute judgment of stimulus "value." However, value is rarely assigned in absolute terms in real-life situations, where one alternative or experience is often evaluated alongside others, and value judgments are made in relative terms. In the current study, we examined performance on a preference task that requires individuals to differentiate between the relative values of different stimuli. In this task, subjects were presented with many pairs of moderately positive stimuli and asked to indicate which stimulus they preferred in each pair. Resulting data indicated the rank order of preference across stimuli and the consistency of their transitive mapping (ie, if A > B and B > C, then A should be > C). Individuals with SZ (n = 38) were both less consistent in their rankings of stimuli and more likely to have larger magnitudes of discrepant responses than control subjects (n = 27). Furthermore, CN showed clear differentiation between different valence categories of stimuli (ie, highly positive > mildly positive > mildly negative > highly negative); while individuals with SZ showed the same general pattern of results but with less differentiation between the valence levels. These data suggest that individuals with SZ are impaired in developing or maintaining nuanced representations of the different attributes of a stimulus, thus making stimuli of similar general value easily confusable.

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Available from: Michael Joshua Frank, Oct 06, 2015
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    • "However, rules guiding behaviour do not apply equally to all situations, and we need to alter which rules we use depending on the context. The inability to adapt to changing situations is a hallmark of many human psychiatric disorders (Gold et al., 2008, 2009; Strauss et al., 2011). "
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    European Journal of Neuroscience 08/2015; DOI:10.1111/ejn.13042 · 3.18 Impact Factor
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    • "Indeed, schizophrenia subjects experience more intense negative and less intense positive emotions than healthy subjects using a structured time-sampling technique during daily life (Myin-Germeys et al., 2000). These heterogeneous findings indicate that valence ratings are strongly influenced by the applied methodological approach (Strauss et al., 2011). The valence rating used in our study might not represent subjective experience but rather a cognitive categorisation. "
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    ABSTRACT: Dysfunctional emotion processing in patients suffering from schizophrenia is a prominent clinical feature of great importance for social functioning and subjective well-being. The neurobiological underpinnings are still poorly understood. Here we investigated a large sample of schizophrenia patients and matched healthy controls with an event-related fMRI task during emotion processing using emotional pictures from the International Affective Picture System (IAPS). Schizophrenia patients revealed stronger right amygdala activation during negative and attenuated response during positive affective picture processing compared to healthy controls. Further analysis indicated that medication status influences activation of the ventral anterior cingulate cortex during negative affective stimuli processing. These results might represent a correlate of altered emotional experience in schizophrenia patients who are known to report less positive and more negative affective states in daily life situations.
    Schizophrenia Research 08/2013; 150(1). DOI:10.1016/j.schres.2013.07.015 · 3.92 Impact Factor
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    • "A number of studies have reported evidence for impaired representation of the value of positive outcomes, or in using this information to effectively and adaptively guide goal-directed behavior in patients (Barch and Dowd, 2010; Gold et al, 2008). In particular, patients appear severely impaired in situations that require relative value judgments (Strauss et al, 2011), as in the effort-related choice procedure and the concurrent schedules used in the current studies. "
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