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New perspectives in MicroRNA regulation of innate immunity.

Michael P Gantier

Centre for Cancer Research, Monash Institute of Medical Research, Monash University , Clayton, Victoria, Australia.

Journal Article: Journal of interferon & cytokine research: the official journal of the International Society for Interferon and Cytokine Research (impact factor: 1.63). 05/2010; 30(5):283-9. DOI: 10.1089/jir.2010.0037

Abstract

The fine-tuning of the innate immune response by microRNAs (miRNAs) is a concept now supported by a rapidly growing body of evidence. Target prediction analyses indicate that up to a half of innate immune genes could be under the direct regulation of miRNAs. However, the extent to which miRNAs regulate innate immunity remains poorly defined and is currently limited to a handful of target genes. This review highlights several important parameters of miRNA regulation, mostly neglected in the field, which underpin the relevance of miRNAs in the regulation of innate immunity.

Source: PubMed

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Keywords

direct regulation
 
growing body
 
innate immune genes
 
innate immune response
 
innate immunity
 
limited
 
miRNA regulation
 
miRNAs
 
target genes
 
Target prediction analyses