Constraint of DNA on Functionalized Graphene Improves its Biostability and Specificity

Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Small (Impact Factor: 8.37). 06/2010; 6(11):1205-9. DOI: 10.1002/smll.201000024
Source: PubMed


The single-stranded DNA constrained on graphene surface is effectively protected from enzymatic cleavage by DNase I. The anisotropy, fluorescence, NMR, and CD studies suggest that the single-stranded DNA is promptly adsorbed onto graphene forming strong molecular interactions. Furthermore, the constraint of DNA probe on graphene improves the specificity of its response to complementary DNA. These findings will promote the further application of graphene in biotechnology and biomedical fields.

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