Article

Effect of ethanol on sleep-awake state in sleep-disturbed rats.

Department of Medicinal Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 1-1-1 Tsushima-Naka, Kita-ku, Okayama 700-8530, Japan.
Biological & Pharmaceutical Bulletin (impact factor: 1.66). 01/2010; 33(5):849-53. pp.849-53
Source: PubMed

ABSTRACT The present study was undertaken to investigate the effect of ethanol on the sleep-wake cycle in normal rats and sleep-disturbed rats. In normal rats, no significant difference was observed by ethanol in sleep latency, total awake time and total non-rapid eye movement (NREM) sleep time, except for total REM sleep time. On the other hand, in sleep-disturbed rats, ethanol at doses of 1 and 2 g/kg caused significant decreases in sleep latency and total wake time, and an increase in total NREM sleep time. In addition, ethanol showed a significant increase in delta activity in the sleep-disturbed model rat, different from triazolam. These results suggested that ethanol had not only a hypnotic but also a sleep-maintaining effect in sleep-disturbed rats at reasonable blood ethanol concentrations.

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Keywords

delta activity
 
different
 
ethanol
 
hypnotic
 
normal rats
 
reasonable blood ethanol concentrations
 
significant decreases
 
sleep-disturbed model rat
 
sleep-disturbed rats
 
sleep-wake cycle
 
total awake time
 
total non-rapid eye movement
 
total NREM
 
total REM
 
total wake time
 
triazolam
 

Yoshihito Obara