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ChemInform Abstract: Allenamide Hydro-Hydroxyalkylation: 1,2-Amino Alcohols via Ruthenium-Catalyzed Carbonyl anti-Aminoallylation.

University of Texas at Austin, Department of Chemistry and Biochemistry, Austin, Texas 78712, USA.
Organic Letters (Impact Factor: 6.32). 06/2010; 12(11):2514-6. DOI: 10.1021/ol1007235
Source: PubMed

ABSTRACT Exposure of alcohols to allenamides in the presence of RuHCl(CO)(PPh(3))(3) and dippf [dippf = bis(diisopropylphosphino)ferrocene] results in hydrogen transfer to generate aldehyde-allylruthenium pairs, which engage in C-C coupling to form products of carbonyl aminoallylation as single anti-diastereomers.

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