Trastuzumab Pharmacokinetics Influenced by Extent Human Epidermal Growth Factor Receptor 2-Positive Tumor Load

University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Journal of Clinical Oncology (Impact Factor: 18.43). 05/2010; 28(21):e355-6; author reply e357. DOI: 10.1200/JCO.2010.28.4604
Source: PubMed
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    • "Recently, another study indicated that trastuzumab pharmacokinetics and organ distribution can also be heavily affected by an extensive tumor load [31]. Therefore, a study with a more patient-tailored trastuzumab dosing schedule on the basis of tumor volume in addition to bodyweight should be considered in the future. "
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