Article

Analysis of plasma D-dimer concentration in patients with delayed pressure urticaria.

Chair and Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland.
Journal of the European Academy of Dermatology and Venereology (impact factor: 2.98). 04/2010; 25(2):232-4. DOI:10.1111/j.1468-3083.2010.03699.x pp.232-4
Source: PubMed

ABSTRACT Activation of fibrinolysis system has been observed in spontaneous urticaria.
To investigate the haemostatic activation in DPU, expressed by plasma D-dimer concentration, the index of active fibrinolysis.
Plasma D-dimer concentrations were measured in eight patients with pure DPU of varying severity as well as in 30 healthy subjects.
The analysis of individual results indicated that three patients of the eight show d-dimer concentration higher than the upper limit of the normal range. All the patients had severe DPU and manifested extensive lesions. The remaining five milder cases showed values within the normal range.
Our analysis revealed that DPU patients may differ in their haemostatic activation state depending on severity of the disease. In severe DPU cases hyperfibrinolysis may occur, manifested by elevated plasma d-dimer concentration, probably as a consequence of the systemic inflammatory response.

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Keywords

30 healthy subjects
 
Activation
 
d-dimer concentration higher
 
DPU patients
 
haemostatic activation
 
haemostatic activation state
 
manifested extensive lesions
 
normal range
 
patients
 
plasma D-dimer concentration
 
Plasma D-dimer concentrations
 
severe DPU cases hyperfibrinolysis
 
severity
 
systemic inflammatory response
 
three patients
 
upper limit
 
varying severity
 

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