Asymptomatic spinal cord involvement in posterior reversible encephalopathy syndrome

Neurology (Impact Factor: 8.29). 05/2010; 74(18):1478-9; author reply 1479. DOI: 10.1212/WNL.0b013e3181d8a4a3
Source: PubMed
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    ABSTRACT: Both progressive multifocal leukoencephalopathy (PML) and posterior reversible encephalopathy syndrome (PRES) have been reported as complications of rituximab therapy. These disorders may appear indistinguishable on magnetic resonance imaging (MRI). We report on a 42 year old woman with neuromyelitis optica (NMO) of 10 years duration who developed extensive white matter disease affecting chiefly both parietal lobes 6 months after her first and only dose of rituximab. The MRI findings suggested the diagnosis of PML, but her history was more consistent with PRES. Ultimately, a brain biopsy was performed which was consistent with the diagnosis of PRES. PRES and PML may have overlapping symptomatology and be indistinguishable on MRI. An approach to distinguishing between these two disorders is addressed. Copyright © 2014. Published by Elsevier B.V.
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    ABSTRACT: Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state, which is associated with symmetrical subcortical areas of vasogenic oedema that are preferentially parieto-occipital, and it typically resolves within a few weeks after appropriate treatment, We hereby report a case of a female with adrenal tumour presenting with PRES, who was featured by a very rare neuroimaging manifestation, the involvement of cervical cord and medulla. © 2015, Journal of Clinical and Diagnostic Research. All rights reserved.
    Journal of Clinical and Diagnostic Research 03/2015; 9(1):CD01-2. DOI:10.7860/JCDR/2015/10756.5376 · 0.23 Impact Factor