Primary pulmonary extranodal marginal zone lymphoma/low grade B-cell lymphoma of MALT type combined with well-differentiated adenocarcinoma.

Department of Pathology, Dokuz Eylül University, Faculty of Medicine, Izmir, Turkey.
Tumori (Impact Factor: 1.27). 01/2010; 96(1):168-71.
Source: PubMed


We describe a rare case of extranodal marginal zone/low-grade B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) combined with areas of well-differentiated adenocarcinoma. In addition, the MALT lymphoma was synchronously systemic, with involvement of the lung, stomach and duodenum.

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Available from: Duygu Gürel, Apr 29, 2014
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    • "Concurrent adenocarcinoma and MALT lymphoma have been previously documented in the stomach, where Helicobacter pylori infection seemed to be responsible for both diseases [3] [4]. Concurrent lung adenocarcinoma and BALT lymphoma have been scarcely reported in the literature, and there are speculations that a genetic linkage between the AP12-MALT1 fusion gene and the high incidence of trisomy 3 seen in MALT lymphoma may coexist with the development of lung adenocarcinoma [3] [4]. It remains to be investigated if there is also some genetic linkage between the development of BALT lymphoma and squamous cell lung carcinoma. "
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    ABSTRACT: A 72-year-old man presented with weight loss, fever, and malaise. Chest radiograph and CT revealed two large ill-defined masses in middle and left lower lobes. CT-guided biopsy of left lower lobe mass disclosed bronchus-associated lymphoid tissue (BALT) lymphoma. Middle lobe mass was considered second deposit in contralateral lung. The patient received chemotherapy for BALT. Followup CT disclosed regression of left lower lobe mass and stability of middle-lobe mass and of right paratracheal lymph nodes. CT-guided biopsy of middle-lobe mass revealed squamous cell lung carcinoma. Surgical biopsy of right paratracheal lymph nodes revealed malignancy. Disease was staged T3, N2, and M0. Combined chemotherapy for lung cancer and BALT lymphoma was initiated.
    Case Reports in Oncological Medicine 02/2013; 2013:420393. DOI:10.1155/2013/420393