International Journal of Pharmacy and Technology 01/2010;
Source: DOAJ

ABSTRACT An attempt has been made for the development of fast dissolving tablets of the carbamazepine by solid dispersion methods, using different concentrations of croscarmellose sodium as superdisintegrating agent. The major problem of this drug is very low solubility in biological fluids and poor bioavailability after oral administration. The tablets prepared were evaluated for hardness, friability,drug content, disintegrating time, wetting time and in-vitro dissolution studies. The formulations prepared with mannitol solid dispersion were showed disintegration time between the ranges of 12.83 –16.79 sec and Drug release showed between the ranges of 08 – 10 min. However the formulations prepared with PEG-6000 solid dispersion did not disintegrate in specified limit of time for fastdissolving tablet. Among all formulations SM4 showed 99.50 % drug release within 8 minutes. The prepared tablets were characterized by DSC and FTIR Studies. No chemical interaction between drug and excipient was confirmed by DSC and FTIR studies. The stability study conducted as per the ICH guidelines and the formulations were found to be stable. The results concluded that fast dissolving tablets of poorly soluble drug, carbamazepine showing enhanced dissolution, improved bioavailability,effective therapy and hence better patient compliance.

170 Reads
  • Source
    Occupational and Environmental Medicine 01/1997; DOI:10.1136/oem.54.1.69 · 3.27 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: In order to make a compressed tablet which can rapidly disintegrate in the oral cavity, microcrystalline cellulose and low-substituted hydroxypropylcellulose were used as disintegrants, and ethenzamide and ascorbic acid were chosen as poorly and easily water soluble model drugs, respectively. The mixture of microcrystalline cellulose and low-substituted hydroxypropylcellulose was compressed at 100--500 kgf in the absence of an active ingredient. The properties of these tablets, such as hardness, porosity, the time required for complete wetting of a tested tablet (wetting time), water uptake and disintegration time determined by a new disintegration apparatus, were investigated to elucidate the wetting and disintegration characteristics of these tablets, When the MCC/L-HPC ratio was in the range of 8:2 to 9:1, the shortest disintegration time was observed. The disintegration of tablets containing ethenzamide or ascorbic acid was examined next. Tablet disintegration time in the oral cavity was also tested, and good correlation between the disintegration behaviors in vitro and in the oral cavity was recognized.
    CHEMICAL & PHARMACEUTICAL BULLETIN 12/1996; 44(11):2121-7. DOI:10.1248/cpb.44.2121 · 1.16 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: In this report, rapidly disintegrating tablets were developed using both direct compression and wet compression methods. Tablet properties, such as porosity, tensile strength, wetting time and disintegration time were evaluated, and the formation and disintegration mechanisms of the tablets were elucidated. Formulation and preparation conditions were optimized using polynomial regression or artificial neural network (ANN).
    Powder Technology 01/2002; 122(2-3-122):188-198. DOI:10.1016/S0032-5910(01)00415-6 · 2.35 Impact Factor


170 Reads
Available from