Effect of early intervention on 5-year outcome in non-affective psychosis

Institute of Psychiatry, Kings Health Partners, London, UK.
The British journal of psychiatry: the journal of mental science (Impact Factor: 7.99). 05/2010; 196(5):372-6. DOI: 10.1192/bjp.bp.109.066050
Source: PubMed


Early specialised care may improve short-term outcome in first-episode non-affective psychosis, but it is unclear if these benefits endure.
To assess the long-term effect of early intervention in psychosis.
Individuals with first-episode psychosis were randomised to specialised care or care as usual (trial number: ISRCTN73679874). Outcome after 5 years was assessed by case-note review.
There were no significant differences in the admission rate (coefficient 0.096, 95% CI -0.550 to 0.742, P = 0.770) or the mean number of bed days (coefficient 6.344, 95% CI -46 to 58.7, P = 0.810).
These findings that specialist intervention did not markedly improved outcome at 5 years accord with those from a larger OPUS study. The sample size of this study was small and these results should be generalised with caution. More research is needed.

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