[Show abstract][Hide abstract] ABSTRACT: β-Cell regeneration and β-cell preservation are two promising therapeutic approaches for the management of patients with type 1 diabetes (T1D). Stem cell-based strategies to address the problems of shortage in β cells, autoimmune and alloimmune responses have become an area of intense study.
This review focuses on the progress that has been made in obtaining functional, insulin-producing cells from various types of stem/progenitor cells, including the current knowledge on the immunomodulatory roles of hematopoietic stem cell and multipotent stromal cell in the therapies for T1D.
A broad overview of recent advancements in this field is provided. The hurdles that remain in the path of using stem cell-based strategies for the treatment of T1D and possible approaches to overcome these challenges are discussed.
Stem cell-based strategies hold great promise for the treatment of T1D. In spite of the progress that has been made over the last decade, a number of obstacles and concerns need to be cleared before widespread clinical application is possible. In particular, the mechanism of ESC and iPSC-derived β-cell maturation in vivo is poorly understood.
[Show abstract][Hide abstract] ABSTRACT: A scientific review presents biomaterials for the feeder-free culture of human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC). Tissue-specific stem cell niches provide crucial cell-cell contacts and paracrine signaling. The extracellular matrix ECM) keeps stem cells in the niche and serves to initiate signal transduction, while locally concentrated glycosaminoglycans (GAGs) provide soluble growth factors or cytokines. It will be highly beneficial to design, construct, and reproduce the microenvironment and niche of pluripotent stem cells in vitro with biomacromolecules and synthetic polymers. Culture materials derived from biomacromolecules and synthetic polymers have been used to support the propagation of hESCs and human iPSCs while maintaining their pluripotency.
Chemical Reviews 02/2011; 111(5):3021-35. DOI:10.1021/cr1003612 · 46.57 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Advances of regenerative medicine in the therapy of type 1 di abetes mellitus. І. Sources of b-cell production (literature review) (part 2)
M.D. Tronko, I.P. Pasteur
State institution «V.P. Komisarenko Institute of Endocrinology and Metabolism, Natl Acad. Med. Sci. of Ukraine»
Summary. Modern scientific data are presented in the review, on the advances of regenerative medicine in the search for sources generating insulin-producing cells for the therapy of type 1 diabetes mellitus.
Keywords: type 1 diabetes mellitus, stem cells, insulin-producing cells.
Note: This list is based on the publications in our database and might not be exhaustive.
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.