• [Show abstract] [Hide abstract]
    ABSTRACT: This review outlines the recent progress during the last 25 years concerning the biotransformation of exogenous substrates by plant cultured cells. The plant cultured cells have abilities of the regio- and stereoselective hydroxylation, oxido-reduction, hydrogenation, glycosylation, and hydrolysis for various organic compounds as well as microorganisms. The reaction types and the stereochemistry of the products involved in the biotransformations are described. The development of techniques using immobilized plant cells are also delineated.
    Journal of Molecular Catalysis B Enzymatic 09/2003; 23(2-6):145-170. DOI:10.1016/S1381-1177(03)00080-8 · 2.75 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Bioassay-guided fractionation of the organic extracts of whole plants of Mostuea brunonis (Loganiaceae), using the National Cancer Institute's (NCI) human tumor-based in vitro antitumor screen, led to the isolation and identification of camptothecin 20-O-beta-D-glucoside (1) and three moderately cytotoxic alkaloids, the known deoxypumiloside (2) and strictosamide (3), and the new 2'-O-acetylstrictosamide (4), from the cytotoxic alkaloid fractions. While the previously unknown 20-O-beta-D-glucopyranosyl camptothecin exhibited greater solubility in alcohol, DMSO-H(2)O and H(2)O than camptothecin, it was essentially inactive in the NCI's in vitro 60-cell line primary antitumor screen. However, it could be vulnerable to de-glucosidation in vivo, and may, therefore, merit additional evaluation as a potential prodrug of camptothecin that could be more readily formulated than the parent agent.
    Journal of Natural Products 11/1999; 62(10):1427-9. · 3.95 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Three major metabolites of mefenamic acid were isolated from the urine of a normal adult man receiving mefenamic acid orally. The structures of those metabolites were determined as glucuronides of mefenamic acid, its hydroxymethyl derivative, and its carboxylic acid derivative on the basis of spectral data.
    Biological & Pharmaceutical Bulletin 09/1993; 16(8):811-2. DOI:10.1248/bpb.16.811 · 1.78 Impact Factor

Full-text

Download
3 Downloads
Available from
Apr 6, 2015