BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia

IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardetina, 306, 00179 Rome, Italy.
European Psychiatry (Impact Factor: 3.44). 10/2010; 25(6):311-3. DOI: 10.1016/j.eurpsy.2009.10.008
Source: PubMed


Brain-derived neurotrophic factor (BDNF) gene variants may potentially influence behaviour. In order to test this hypothesis, we investigated the relationship between BDNF Val66Met polymorphism and aggressive behaviour in a population of schizophrenic patients. Our results showed that increased number of BDNF Met alleles was associated with increased aggressive behaviour.

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Available from: Gianfranco Spalletta, Dec 16, 2014
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    • "BDNF affects susceptibility to environmental stressors in the prediction of impulsive aggression (Wagner, Baskaya, Dahmen, Lieb, & Tadić, 2010) with met-allele carriers being more vulnerable to environmental risk than valval carriers. Moreover, carriers of the met-allele show an increased risk for psychopathological disorders related to aggression (e.g., Spalletta et al., 2010) and impulsivity (Oades et al., 2008). In line with previous research, Kretschmer et al. (2014) showed a stronger effect of peer on adolescents' own aggression in carriers of the met-met variant of this polymorphism. "
    Handbook of biosocial criminology, Edited by Matt DeLisi, Matthew G. Vaughn, 01/2015: pages 101-114; Routledge.
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    • "Supporting an additive risk model, val-homozygotes were assigned a score of 0, val-met heterozygotes were assigned a score of 1, and met-met homozygotes were assigned a score of 2. Thus, each met-allele was assumed to add to individual genetic risk as has been found with regard to other phenotypes, including aggression (Spalletta et al., 2010) and in interplay with maternal care on personality traits (Suzuki et al., 2011). "
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    ABSTRACT: Peer antisocial behavior robustly predicts adolescents' own behavior but not all adolescents are equally vulnerable to their peers' influence and genetic factors may confer vulnerability. This study used data of n = 3081 adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) to examine whether BDNF, a polymorphism that affects psychological functioning, moderates the association between affiliation with aggressive peers at age 10 and own aggression at age 15. A significant gene-environment interaction was found, where those who affiliated with aggressive peers in childhood showed increased risk for being aggressive in adolescence if they carried the BDNF met-met variant compared to val-val carriers. Our findings underline the importance of both biological and social factors for adolescent development.
    Journal of Research on Adolescence 03/2014; 24(1):177-185. DOI:10.1111/jora.12050 · 1.99 Impact Factor
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    • "Links between ADHD and the BDNF gene are important as the ADHD phenotype overlaps significantly with aggression and impulsivity phenotypes. Additionally, polymorphisms found within the BDNF gene have been predictive of aggressive behavior in schizophrenic patients (Spalletta et al. 2009). Similar work from Brody et al. (2009) has found an interaction between environmental factors and the serotonin transporter gene in relation to prevention efforts. "
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    ABSTRACT: A variety of school-based, universal preventive interventions have been developed to address behavioral and mental health problems. Unfortunately, few have been evaluated within the context of randomized controlled trials with long-term follow-up. Even fewer still have examined the potential genetic factors that may drive differential impact of the intervention. In the present analysis, we examine the extent to which the longitudinal effects of two elementary school-based interventions were moderated by the brain-derived neurotrophic factor (BDNF) gene, which has been linked with aggression and impulsive behaviors. The sample included 678 urban, primarily African American children who were randomly assigned along with their teachers to one of three first grade classroom conditions: classroom-centered (CC) intervention, Family School Partnership (FSP), or a control condition. The teacher ratings of the youth's aggressive and impulsive behavior were obtained at baseline and in grades 6-12. Single-nucleotide polymorphisms (SNPs) from the BDNF gene were extracted from the genome-wide data. Longitudinal latent trait-state-error models indicated a significant interaction between a particular profile of the BDNF SNP cluster (46 % of sample) and CC intervention on impulsivity (β = -.27, p < .05). A similar interaction was observed for the BDNF SNP cluster and the CC intervention on aggression (β = -.14, p < .05). The results suggest that the impacts of preventive interventions in early elementary school on late adolescent outcomes of impulsivity and aggression can be potentially modified by genetic factors, such as BDNF. However, replication of these results is necessary before firm conclusions can be drawn.
    Prevention Science 11/2013; 15(6). DOI:10.1007/s11121-013-0441-3 · 2.63 Impact Factor
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