BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia

IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardetina, 306, 00179 Rome, Italy.
European Psychiatry (Impact Factor: 3.44). 10/2010; 25(6):311-3. DOI: 10.1016/j.eurpsy.2009.10.008
Source: PubMed


Brain-derived neurotrophic factor (BDNF) gene variants may potentially influence behaviour. In order to test this hypothesis, we investigated the relationship between BDNF Val66Met polymorphism and aggressive behaviour in a population of schizophrenic patients. Our results showed that increased number of BDNF Met alleles was associated with increased aggressive behaviour.

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Available from: Gianfranco Spalletta, Dec 16, 2014
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    • "BDNF affects susceptibility to environmental stressors in the prediction of impulsive aggression (Wagner, Baskaya, Dahmen, Lieb, & Tadić, 2010) with met-allele carriers being more vulnerable to environmental risk than valval carriers. Moreover, carriers of the met-allele show an increased risk for psychopathological disorders related to aggression (e.g., Spalletta et al., 2010) and impulsivity (Oades et al., 2008). In line with previous research, Kretschmer et al. (2014) showed a stronger effect of peer on adolescents' own aggression in carriers of the met-met variant of this polymorphism. "

    Handbook of biosocial criminology, Edited by Matt DeLisi, Matthew G. Vaughn, 01/2015: pages 101-114; Routledge.
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    • "Supporting an additive risk model, val-homozygotes were assigned a score of 0, val-met heterozygotes were assigned a score of 1, and met-met homozygotes were assigned a score of 2. Thus, each met-allele was assumed to add to individual genetic risk as has been found with regard to other phenotypes, including aggression (Spalletta et al., 2010) and in interplay with maternal care on personality traits (Suzuki et al., 2011). "
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    ABSTRACT: Peer antisocial behavior robustly predicts adolescents' own behavior but not all adolescents are equally vulnerable to their peers' influence and genetic factors may confer vulnerability. This study used data of n = 3081 adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) to examine whether BDNF, a polymorphism that affects psychological functioning, moderates the association between affiliation with aggressive peers at age 10 and own aggression at age 15. A significant gene-environment interaction was found, where those who affiliated with aggressive peers in childhood showed increased risk for being aggressive in adolescence if they carried the BDNF met-met variant compared to val-val carriers. Our findings underline the importance of both biological and social factors for adolescent development.
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    • "Links between ADHD and the BDNF gene are important as the ADHD phenotype overlaps significantly with aggression and impulsivity phenotypes. Additionally, polymorphisms found within the BDNF gene have been predictive of aggressive behavior in schizophrenic patients (Spalletta et al. 2009). Similar work from Brody et al. (2009) has found an interaction between environmental factors and the serotonin transporter gene in relation to prevention efforts. "
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