How Late-Life Depression Affects Cognition: Neural Mechanisms

Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1695 Northwest 9th Avenue, Suite 3308, Miami, FL 33136, USA.
Current Psychiatry Reports (Impact Factor: 3.24). 02/2010; 12(1):34-8. DOI: 10.1007/s11920-009-0081-2
Source: PubMed


Late-life depression is a major health problem and a significant cause of dysfunction that warrants closer evaluation and study. In contrast to younger depressed patients, most depressed older adults suffer more severe variants of the disorder, including significant cognitive impairments. These cognitive changes add to the severity of symptoms and disability that older depressed patients face and likely reflect compromise of certain neural circuits, linking cognitive impairment to late-life depression. Studies examining clinical correlates, neuropsychological testing, and functional and anatomic imaging have yielded a clearer understanding of the neural mechanisms underlying cognitive deficits in late-life depression. This article discusses cognitive impairment in geriatric depression and how developing a better understanding of its neural correlates may lead to improved understanding and outcome of this specific disorder.

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    • "Both depression and cardiovascular diseases (CVDs) are risk factors for cognitive impairment [7], but the various neuropsychological mechanisms underlying LLD can lead to different patterns of cognitive impairment [8]. The current association between depression and cognitive impairment agrees with previous studies [9,10]. "
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    • "Depression in persons with CogI is marked by abnormalities on neuropsychological tests [44] including impairments in memory, attention, and executive function, such as problem solving (for a review see [45]). Patients with major depressive disorder continue to show deficits in attention and executive function even after remission [46]. "
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    • "l›nmam›fl olmas›na karfl›n, bâz› hastalar›n biliflsel yetilerinin kötü oldu¤u tesbit edilmifltir. Geriye dönük bir inceleme yap›ld›¤› için depresyonu olan tüm hastalar›n biliflsel ifllevleri de¤erlendirilememifltir. Yafll›l›k dönemi depresyonunda yürütücü ifllevler, bellek ve dikkat bozukluklar›n›n olabilece¤i bilinmektedir (Lockwood ve ark. 2002, Crocco ve ark. 2010). SMMT kolay uygulanabilen ve biliflsel kay›plar konusunda kabaca fikir veren bir testtir. Çal›flmam›zda, e¤itim y›l› ile SMMT puanlar› aras›nda pozitif korelasyon sap- New/Yeni Symposium Journal •"
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