IOF position statement: Vitamin D recommendations for older adults

Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA.
Osteoporosis International (Impact Factor: 4.17). 07/2010; 21(7):1151-4. DOI: 10.1007/s00198-010-1285-3
Source: PubMed


This position paper of the International Osteoporosis Foundation makes recommendations for vitamin D nutrition in elderly men and women from an evidence-based perspective.

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    • "Several therapeutic options are available for the treatment or prevention of osteoporosis [5,6], and some of these drugs were proven to be efficacious and safe in Taiwanese population studies [7-10]. Among the osteoporosis management factors, vitamin D plays an important role [11,12]. Vitamin D is absorbed from food or synthesized in skin that is exposed to sunlight. "
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    ABSTRACT: Background Vitamin D is essential for calcium metabolism, Vitamin D deficiency can precipitate osteoporosis, cause muscle weakness and increase the risk of fracture. The aim of this study was to assess the prevalence of vitamin D inadequacy among non-supplemented postmenopausal women with osteoporosis and fragility fractures of the hip or vertebrae in Taiwan. Methods This multi-center, cross-sectional, observational study analyzed the vitamin D inadequacy [defined as 25(OH) D level less than 30 ng/mL] in Taiwanese postmenopausal osteoporotic patients who suffered from a low trauma, non-pathological fragility hip or vertebral fracture that received post-fracture medical care when admitted to hospital or at an outpatient clinic. Results A total of 199 patients were enrolled at 8 medical centers in Taiwan; 194 patients met the study criteria with 113 (58.2%) and 81 (41.8%) patients diagnosed with hip and vertebral fracture, respectively. The mean serum 25(OH) D level was 21.1 ± 9.3 ng/mL, resulting in a prevalence of vitamin D inadequacy of 86.6% of the patients. Conclusions High prevalence of vitamin D inadequacy across all age groups was found among non-supplemented women with osteoporosis and fragility hip or vertebral fracture in Taiwan.
    BMC Musculoskeletal Disorders 07/2014; 15(1):257. DOI:10.1186/1471-2474-15-257 · 1.72 Impact Factor
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    • "All patients with DM should be counseled regarding their risk of osteoporosis and fractures. They should also be advised on adequate calcium (at least 100–1200 mg/day) and vitamin D (800–1000 IU/day) intake [110, 111]. When a patient meets guidelines for treatment, there are several options including antiresorptive medications such as bisphosphonates, denosumab, SERM, and anabolic agent teriparatide. "
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    ABSTRACT: It is well established that osteoporosis and diabetes are prevalent diseases with significant associated morbidity and mortality. Patients with diabetes mellitus have an increased risk of bone fractures. In type 1 diabetes, the risk is increased by ∼6 times and is due to low bone mass. Despite increased bone mineral density (BMD), in patients with type 2 diabetes the risk is increased (which is about twice the risk in the general population) due to the inferior quality of bone. Bone fragility in type 2 diabetes, which is not reflected by bone mineral density, depends on bone quality deterioration rather than bone mass reduction. Thus, surrogate markers and examination methods are needed to replace the insensitivity of BMD in assessing fracture risks of T2DM patients. One of these methods can be trabecular bone score. The aim of the paper is to present the present state of scientific knowledge about the osteoporosis risk in diabetic patient. The review also discusses the possibility of problematic using the study conclusions in real clinical practice.
    International Journal of Endocrinology 06/2014; 2014(3):820615. DOI:10.1155/2014/820615 · 1.95 Impact Factor
    • "The mean ± standard deviation (SD) levels of the parameters studied are shown in Table 1. In the study cohort, only 5.6% subjects (4/71) had normal 25-OHD level (taken as being >30 ng/ml) and 7.0% (5/71) had vitamin D insufficiency (25-OHD levels between 20 and 30 ng/ml) while 87.3% (62/71) were vitamin D deficient (<20 ng/ml).[11] "
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    ABSTRACT: The purpose of this study is to investigate the association of the serum 25-hydroxyvitamin D (25-OHD) level with markers of insulin resistance (IR) in postmenopausal Indian women. This was a cross-sectional study, conducted at a Tertiary Care Hospital in New Delhi, India. Seventy one postmenopausal women (mean age 56.3 ± 7.6 years) were enrolled. Exclusion criteria were known or newly detected diabetics, subjects with chronic renal failure, chronic liver disease or any other chronic inflammatory condition, chronic smokers and chronic alcoholics. Serum calcium (and albumin for calculating corrected calcium), phosphorus, alkaline phosphatase and 25-OHD were measured as parameters of calcium homeostasis. Fasting blood glucose (FBG), systolic and diastolic blood pressures, body mass index (BMI), fasting serum insulin, calculated glucose insulin ratio (GIR), and homeostatic model assessment of insulin resistance (HOMA-IR) were studied as parameters of IR. Data was then analyzed for statistical significance. The mean serum 25-OHD level was 12.73 ± 7.63 ng/ml. The mean BMI was 27.78 ± 5.37 kg/m(2). The mean calculated GIR was 13.14 ± 9.39 and HOMA-IR was 2.31 ± 1.70. Serum 25-OHD was inversely correlated with BMI (correlation coefficient -0.234, P value 0.050) and with HOMA-IR (correlation coefficient -0.237, P value 0.047). However, when 25-OHD was adjusted for BMI the correlation between 25-OHD and HOMA-IR lost its significance. No correlation was found between serum 25-OHD and any other parameters of IR studied. There is a significant negative linear correlation between 25-OHD and BMI. The significant negative linear correlation between 25-OHD and HOMA-IR was confounded by BMI. There is no correlation between 25-OHD and parameters of IR.
    03/2014; 18(1):89-93. DOI:10.4103/2230-8210.126583
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