Androgens and obesity.
ABSTRACT As testosterone levels are frequently reduced in obesity, an understanding of the relationship between serum testosterone and adiposity is necessary in the clinical evaluation of these men, in particular when considering testosterone therapy.
Population and interventional data suggest a bi-directional relationship exists between testosterone and obesity in men, with lower total testosterone and sex hormone binding globulin (SHBG) (and to a lesser extent free testosterone) levels than their nonobese peers; obesity having an impact at least as important as ageing. Abnormalities in the hypothalamo-pituitary-testicular axis are seen with increasing obesity. Weight loss in massive obesity increases testosterone levels but its role in mild-moderate obesity is unclear. Testosterone supplementation reduces total body fat in hypogonadal and ageing men although the effects on regional fat distribution are less well described.
Favourable changes in total body fat and regional fat distribution suggest a potential role for testosterone in obesity. However, lifestyle advice to achieve sustained weight loss should be the mainstay of management. Obese men with confirmed androgen deficiency can be offered treatment, whereas in those with low-normal testosterone levels more research is needed.
Article: Utility of the Ultrasound Evaluation of Intraperitoneal Fat in Correlation with Endometrial Cancer[show abstract] [hide abstract]
ABSTRACT: Introduction: In the context of endometrial cancer, visceral obesity as a risk factor is associated with a chronic inflammatory process, confirmed by the increase in inflammatory marker levels. Material and Method: The study is a case-control analysis including 2 groups of patients: group I – 50 patients diagnosed with endometrial cancer, group II – 70 patients without gynecological pathology or inflammatory disorders (control group). The diagnosis of endometrial cancer was made following histopathological examination that evaluated the tissue material obtained following endometrial biopsy. After clinical examination and anthropometric measurements, these patients underwent ultrasound and computer tomography examination by which intraperitoneal fat was determined. All parameters were included in the study database. Results: A significant correlation coefficient was also found between visceral fat evaluated by CT and visceral fat assessed by US (r =0.96, p<0.0001). In the case of the control group, the mean visceral fat area was 159.14±42.5 cm²), while in the group of patients with endometrial cancer, the mean visceral fat area was 251.37±59.78 cm². Thus, there is a statistically significant difference in intraperitoneal fat between the two groups (p<0.0001). Conclusions: A visceral fat area larger than 250 cm² is a risk factor for endometrial cancer. The measurement of visceral fat by US can be a screening method for endometrial cancer in obese patients.Applied Medical Informatics. 01/2011;
Article: Low testosterone associated with obesity and the metabolic syndrome contributes to sexual dysfunction and cardiovascular disease risk in men with type 2 diabetes.Diabetes care 07/2011; 34(7):1669-75. · 8.09 Impact Factor