Article

An evaluation of the utility of routine laboratory monitoring of juvenile idiopathic arthritis (JIA) patients using non-steroidal anti-inflammatory drugs (NSAIDs): a retrospective review

Pediatric Rheumatology 01/2010; DOI:http://www.doaj.org/doaj?func=openurl&genre=article&issn=15460096&date=2010&volume=8&issue=1&spage=11
Source: DOAJ

ABSTRACT Abstract

Background

No consensus evidence-based guidelines for the routine laboratory monitoring of children with JIA receiving non-steroidal anti-inflammatory drugs (NSAIDs) exist. The purpose of this study is to evaluate the clinical utility of routine laboratory monitoring of hemoglobin, transaminases, blood urea nitrogen, serum creatinine, and urinalysis in patients with juvenile idiopathic arthritis (JIA) receiving NSAIDs.

Methods

The medical records of 91 children with JIA followed between 1996 and 2006 were retrospectively reviewed for laboratory results and clinically significant adverse effects attributed to NSAID use. Laboratory abnormalities were documented, with potential adverse clinical sequelae, including if NSAID use was discontinued.

Results

Abnormal laboratory results were recorded for 24 of 91 patients. Nearly all abnormalities were mild and not associated with adverse clinical sequelae. All patients but one continued to receive NSAID therapy after the abnormality was detected.

Conclusions

Although detection of abnormal laboratory values occurred while on NSAIDs, these abnormalities did not correlate with adverse clinical signs and symptoms. The routine monitoring of laboratory tests in asymptomatic children treated with NSAIDs is of questionable utility.

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Keywords

91 children
 
91 patients
 
abnormal laboratory values
 
abnormality
 
adverse clinical sequelae
 
adverse clinical signs
 
asymptomatic children
 
blood urea nitrogen
 
clinical utility
 
clinically significant adverse effects
 
juvenile idiopathic arthritis
 
Laboratory abnormalities
 
medical records
 
non-steroidal anti-inflammatory drugs
 
NSAID therapy
 
NSAID use
 
potential adverse clinical sequelae
 
routine laboratory monitoring
 
routine monitoring
 
serum creatinine