Systematic Analysis of Candidate Genes for Alzheimer's Disease in a French, Genome-Wide Association Study

INSERM U744, Lille, France.
Journal of Alzheimer's disease: JAD (Impact Factor: 4.15). 04/2010; 20(4):1181-8. DOI: 10.3233/JAD-2010-100126
Source: PubMed


We selected twenty genes from the "Top Results" list on the AlzGene database website and assessed their association with risk of developing Alzheimer's disease (AD) in a large, genome-wide association study (using 526 SNPs from 2,032 AD cases and 5,328 controls) performed in France. The APOE, CLU, PICALM, and CR1 loci were excluded, since they had already been extensively analyzed. Ten genes/loci (TFAM, SORL1, CHRNB2, SORCS1, DAPK1, MTHFR, GWA 14q32.13, BDNF, NEDD9, and CH25H) showed weak nominal association with AD risk, in line with previous studies. In the remaining ten genes/loci (TNK1, ACE, CST3, IL1B, hCG2039140, PRNP, GAB2, LOC651924, IL1A, and TF), no single nucleotide polymorphisms were associated in our dataset. Of the genes showing nominal association in our cohorts, TFAM and CHRNB2 appear particularly interesting and warrant further genetic and functional follow-up analyses.

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    • "meta-analysis of several small-scale studies and in a recent French genome wide association study [7] [17]. In both these studies the A allele was associated with AD. "
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