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[Show abstract][Hide abstract] ABSTRACT: A novel three-dimensional (3D) disposable glucose concentration detection chip is presented. The chip comprises a four-layer
polymethyl methacrylate (PMMA) structure and is fabricated using a commercial CO2 laser and a hot-press bonding technique. In the proposed device, the glucose solution is injected into a double parallel
connection micromixer (DPCM) and is mixed with DNS reagent by means of a self-rotation effect. An experimental platform has
been created for multiple reaction process by integrating chip and micro-heater. The fluid streams exiting the two circular
mixing chambers of the DPCM are then combined and mixed further at a T-type microchannel outlet before passing to a collection
chamber. Numerical simulations are performed to analyze the vortex streamline distribution within the DPCM and to estimate
the mixing performance. The numerical results show that a mixing efficiency as high as 92.5% can be obtained at low Reynolds
numbers (Re=12). It is found a good linear relation of R
2=0.9953 from the chip detection method comparing to the traditional method of R
2=0.9976 at DNS reagent and glucose solution volume ratio of 1:1. In addition, the experimental results show that the accuracy
of the glucose concentration measurements obtained using the proposed microfluidic chip is comparable with that of the measurements
obtained using a conventional large-scale detection method. Overall, the results presented in this study indicate that the
DPCM chip provides a rapid and low-cost means of detecting the concentration of glucose solutions.
KeywordsMicromixer–DNS method–CO2 laser machining–Microfluidics
Microfluidics and Nanofluidics 10/2011; 11(4):479-487. DOI:10.1007/s10404-011-0813-6 · 2.53 Impact Factor
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