Long-term clinical outcome of pelvic exenteration in patients with advanced gynecological malignancies
ABSTRACT We evaluated the outcome of pelvic exenteration in women with locally advanced primary or recurrent gynecological malignancies.
All pelvic exenteration procedures performed between 01/2003 and 06/2009 were evaluated. Extent of surgical radicality, operative techniques, and outcome were evaluated. Kaplan-Meier curves were calculated for Overall (OS) and progression-free survival (PFS).
Forty-seven patients (median age: 52.5 years) were evaluated. Ten of 47 patients (21.3%) had a primary and 37(78.7%) a relapsed cancer. Most common (80.8%) site of origin was the cervix. Patients (80.8%) had undergone previous pelvic irradiation. A total exenteration was performed in 32/47 patients (68%). A complete tumor resection was obtained in 23 patients (49%). Thirty-three patients (70.2%) had at least one major complication, including ileus (8.5%), intestinal-fistula (29.8%), ureteral anastomotic insufficiency (6.4%), abscess (6.4%), and cardiothrombotic events (23.4%). At a median follow-up of 7 months (range: 1-42), 22/47 patients (46.8%) died and 22/47 (46.8%) experienced a relapse. Median OS was 4 months (range: 0.1-16) and 22 months (range: 6-42) for patients with versus without postoperative tumor residuals, respectively (P = 0.0006), while median PFS was 4 months (range:0.1-16) versus 12 months (range: 6-42) (P < 0.0001).
Radical pelvic exenteration due to advanced pelvic malignancies may be associated with a high morbidity. Complete tumor resection is associated with a significantly higher overall and PFS.
- SourceAvailable from: Shailesh P Puntambekar
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- "The margin status is an important factor that is consistently associated with prognosis. Overall and progression-free survival are better following complete tumor resection  . Moreover, in previous series by Berek et al.  and Shingleton et al. , no patient survived 3 years following exenteration when the surgical margins were positive. "
ABSTRACT: Objective To present the initial experience with robotic anterior pelvic exenteration in patients with advanced pelvic cancer at Galaxy Care Laparoscopy Institute, Pune, India. Methods A retrospective chart review of data from 10 patients with advanced cervical carcinoma and bladder involvement or with vault recurrence following hysterectomy who were treated at the study hospital between November 2009 and May 2011. Clinicopathologic data and postoperative data including operative time, blood loss, blood transfusions, hospital stay, lymph node yield, and complications were recorded. Results The mean operative time was 180 minutes, the mean blood loss was 110 mL, and the mean duration of hospital stay was 5 days. There were no treatment-related morbidities or mortalities. A mean parametrial clearance of 3 cm with a distal vaginal margin of 3.5 cm was achieved. All patients had tumor-free margins. The mean number of harvested lymph nodes was 24. Six patients had positive lymph nodes on pathologic examination and were treated with chemoradiotherapy. At a median follow-up of 11 months, 8 patients were disease-free. Conclusion Robot-assisted anterior pelvic exenteration had favorable operative, pathologic, and short-term clinical outcomes. A large multicenter study is required to confirm the results.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 07/2014; 126(1). DOI:10.1016/j.ijgo.2013.12.015 · 1.56 Impact Factor
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- "Subsequently, Magrina et al.   classified pelvic exenteration according to levator ani muscle which seemed to be more accurate and useful, classifying the procedure into four groups: supraelevator, infraelevator, infraelevator þ vulvectomy and extended. Overall morbidity after the procedure is close to 70%  . "
ABSTRACT: The aim of this narrative review is to update the current knowledge on the treatment of recurrent cervical cancer based on a literature review. A web based search in Medline and CancerLit databases has been carried out on recurrent cervical cancer management and treatment. All relevant information has been collected and analyzed, prioritizing randomized clinical trials. Cervical cancer still represents a significant problem for public health with an annual incidence of about half a million new cases worldwide. Percentages of pelvic recurrences fluctuate from 10% to 74% depending on different risk factors. Accordingly to the literature, it is suggested that chemoradiation treatment (containing cisplatin and/or taxanes) could represent the treatment of choice for locoregional recurrences of cervical cancer after radical surgery. Pelvic exenteration is usually indicated for selected cases of central recurrence of cervical cancer after primary or adjuvant radiation and chemotherapy with bladder and/or rectum infiltration neither extended to the pelvic side walls nor showing any signs of extrapelvic spread of disease. Laterally extended endopelvic resection (LEER) for the treatment of those patients with a locally advanced disease or with a recurrence affecting the pelvic wall has been described. The treatment of recurrences of cervical carcinoma consists of surgery, and of radiation and chemotherapy, or the combination of different modalities taking into consideration the type of primary therapy, the site of recurrence, the disease-free interval, the patient symptoms, performance status, and the degree to which any given treatment might be beneficial.Surgical Oncology 01/2012; 21(2):e59-66. DOI:10.1016/j.suronc.2011.12.008 · 2.37 Impact Factor
Conference Paper: Quenching of photodarkening in metal-doped chalcogenide amorphous films[Show abstract] [Hide abstract]
ABSTRACT: Photodarkening relaxation under light exposure of a-As<sub>40</sub>Se<sub>60</sub> amorphous films doped with 0.5 at.% of metals Sn, Mn, Sm, Pr or Dy and a-As<sub>50</sub>Se<sub>50</sub> films doped up to 10.0 at.% Sn were studied for their dependence on the type and concentration of impurities and thermal treatment. Both factors reduce photodarkening with the degree of reduction dependent on the type and concentration of impurity. The relaxation process may be described by a stretched exponential with the dispersion parameter 0.4≤α<0.9 and the time constant increasing with impurity concentration or thermal annealing. The results are discussed in context of the "slip-motion" model of photodarkening in chalcogenide glasses.Semiconductor Conference, 2002. CAS 2002 Proceedings. International; 02/2002