Breast-feeding in relation to asthma, lung function, and sensitization in young schoolchildren
ABSTRACT The evidence from previous studies on beneficial effects of breast-feeding in relation to development of asthma is conflicting.
To investigate the relation between breast-feeding and asthma and/or sensitization during the first 8 years of life.
In a birth cohort, children were followed up to 8 years by questionnaires at ages 2 months and 1, 2, 4, and 8 years to collect information on exposures and health effects. Determination of serum IgE antibodies to common inhalant and food allergens was performed at 4 and 8 years. Longitudinal analyses were applied by using general estimated equations. The study population consisted of 3825 children (93% of the original cohort), of whom 2370 gave blood and 2564 performed lung function measurements at 8 years.
Children exclusively breast-fed 4 months or more had a reduced risk of asthma during the first 8 years of life (adjusted odds ratio [OR], 0.63; 95% CI, 0.50-0.78) compared with children breast-fed less than 4 months. At 8 years, reduced risks of sensitization (adjusted OR, 0.79; 95% CI, 0.64-0.99) and asthma in combination with sensitization (adjusted OR, 0.59; 95% CI, 0.37-0.93) were seen among children exclusively breast-fed 4 months or more. This group also had a significantly better lung function measured with peak expiratory flow.
Breast-feeding for 4 months or more seems to reduce the risk of asthma up to 8 years. At this age, a reduced risk was observed particularly for asthma combined with sensitization. Furthermore, breast-feeding seems to have a beneficial effect on lung function.
SourceAvailable from: Claude Ponvert
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ABSTRACT: Background Asthma is a disease affecting many locations throughout the airway. Most studies have used spirometry as the primary assessment of airway obstruction, a method that may be less sensitive in regard to peripheral airway obstruction. The aim of the current study was to elucidate the associations between asthma phenotypes based on age of onset and duration of symptoms and; (1) spirometry, and (2) small airway involvement measured by impulse oscillometry (IOS) in adolescence.Methods Children and adolescents taking part in BAMSE, a prospective birth cohort study, performed spirometry at 8 and 16, and IOS at 16 years of age. Based on data collected in questionnaires, children were categorized to the following groups; “never asthma”, “early transient asthma”, “early persistent asthma”, and “late onset asthma”.ResultsCompared with the never asthma group, all asthma groups were associated with lower FEV1 at 16 years of age (early transient -119 ml, 95% Confidence Interval -204 to -34; early persistent -410 ml, 95%CI -533;-287 and late onset -148 ml, 95%CI -237;-58). Between 8 and 16 years, significantly less increase of FEV1 was observed in the early persistent and late onset groups.The small airway index “R5-20” was significantly associated with active asthma at 16 years, but not transient asthma.Conclusions All asthma phenotypes studied were negatively associated with FEV1 in adolescence. IOS measurements showed that active asthma is associated with small airway impairments. These results provide new insights into the physiology underlying wheezing phenotypes based on age of onset and duration of disease.This article is protected by copyright. All rights reserved.Allergy 02/2015; DOI:10.1111/all.12598 · 6.00 Impact Factor