Article

Caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling.

Institute of Clinical Molecular Biology, Christian Albrechts University, Kiel D-24105, Germany.
Journal of Biological Chemistry (impact factor: 4.77). 04/2010; 285(26):19921-6. DOI:10.1074/jbc.M110.127480 pp.19921-6
Source: PubMed

ABSTRACT Caspase activating and recruitment domain 8 (CARD8) has been implicated as a co-regulator of several pro-inflammatory and apoptotic signaling pathways. In the present study, we demonstrate a specific modulation of NOD2-induced signaling by CARD8 in intestinal epithelial cells. We show that CARD8 physically interacts with NOD2 and inhibits nodosome assembly and subsequent signaling upon muramyl-dipeptide stimulation. Furthermore, CARD8 inhibits the direct bactericidal effect of NOD2 against intracellular infection by Listeria monocytogenes. Thus, CARD8 represents a novel molecular switch involved in the endogenous regulation of NOD2-dependent inflammatory processes in epithelial cells.

0 0
 · 
0 Bookmarks
 · 
50 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

apoptotic signaling pathways
 
Caspase activating
 
direct bactericidal effect
 
endogenous regulation
 
inhibits nodosome assembly
 
intestinal epithelial cells
 
Listeria monocytogenes
 
muramyl-dipeptide stimulation
 
novel molecular
 
pro-inflammatory
 
specific modulation