Article

Distribution and characterization of the Escherichia coli heat-stable enterotoxin (STa) receptor throughout the intestinal tract of newborn camels (Camelus dromedaries).

Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, P. O. Box 3030, Irbid, 22110, Jordan.
Tropical Animal Health and Production (impact factor: 1.12). 04/2010; 42(6):1311-4. DOI:10.1007/s11250-010-9570-x pp.1311-4
Source: PubMed

ABSTRACT Heat-stable enterotoxin (STa) secretion from Enterotoxigenic Escherichia coli (ETEC) is crucial for the pathogenesis of diarrhea in both animal and human. The goal of this study was to investigate the distribution of the STa-specific receptors in the newborn camel's enterocytes and brush border membrane vesicles (BBMVs). Flow cytometric analysis was used to investigate the density of STa-receptors on enterocytes and BBMVs prepared from anterior jejunum, posterior jejunum, ileum, and colon. Strong density and affinity of STa-receptors was present on enterocytes and BBMVs of the ileum compared to that in the other intestinal segments. It was concluded that the ileum is the major target for STa action in newborn camels.

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Keywords

affinity
 
anterior jejunum
 
BBMVs
 
brush border membrane vesicles
 
diarrhea
 
Enterotoxigenic Escherichia coli
 
Flow cytometric analysis
 
Heat-stable enterotoxin
 
major target
 
newborn camel's enterocytes
 
posterior jejunum
 
STa
 
STa action
 
STa-receptors
 
STa-specific receptors
 

Ahmad M Al-Majali