Article

Tenofovir associated hypokalaemia in a patient with normal renal function

Servicio de Enfermedades Infecciosas, Hospital Vall d'Hebron, Barcelona, España.
Enfermedades Infecciosas y Microbiología Clínica (Impact Factor: 1.88). 04/2010; 28(9):655-6. DOI: 10.1016/j.eimc.2009.12.008
Source: PubMed
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    ABSTRACT: Although adverse events in HIV patients taking tenofovir are relatively rare, postmarketing reports of nephrotoxicity have alerted physicians to other potentially serious outcomes. We present a series of 40 patients who developed hypokalemia associated with tenofovir. Identified risk factors included concomitant ritonavir or didanosine use, a lower weight and longer duration of tenofovir use. Recovery or improvement was seen in the majority of patients (66%) after the discontinuation of tenofovir; however, four deaths occurred. The associated consequences of tenofovir-related hypokalemia may be profound and life-threatening.
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