Alcohol intake and pancreatic cancer: A pooled analysis from the pancreatic cancer cohort consortium (PanScan)

Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK.
Cancer Causes and Control (Impact Factor: 2.74). 04/2010; 21(8):1213-25. DOI: 10.1007/s10552-010-9548-z
Source: PubMed

ABSTRACT The literature has consistently reported no association between low to moderate alcohol consumption and pancreatic cancer; however, a few studies have shown that high levels of intake may increase risk. Most single studies have limited power to detect associations even in the highest alcohol intake categories or to examine associations by alcohol type. We analyzed these associations using 1,530 pancreatic cancer cases and 1,530 controls from the Pancreatic Cancer Cohort Consortium (PanScan) nested case-control study. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression, adjusting for potential confounders. We observed no significant overall association between total alcohol (ethanol) intake and pancreatic cancer risk (OR = 1.38, 95% CI = 0.86-2.23, for 60 or more g/day vs. >0 to <5 g/day). A statistically significant increase in risk was observed among men consuming 45 or more grams of alcohol from liquor per day (OR = 2.23, 95% CI = 1.02-4.87, compared to 0 g/day of alcohol from liquor, P-trend = 0.12), but not among women (OR = 1.35, 95% CI = 0.63-2.87, for 30 or more g/day of alcohol from liquor, compared to none). No associations were noted for wine or beer intake. Overall, no significant increase in risk was observed, but a small effect among heavy drinkers cannot be ruled out.

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Available from: Li Jiao, Sep 26, 2015
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    • "Alcohol intake was classified according to the amount of ethanol contained in alcoholic beverage drinks (nonconsumer ; up to 60 grams of ethanol per day or moderate consumer; more than 60 grams of ethanol per day or excessive consumer) (Michaud et al., 2010). Smoking habit was divided into two categories (nonsmoker and smoker), and volunteers who stopped smoking for more than 12 months were included in the category of nonsmokers. "
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    Substance Use &amp Misuse 04/2014; 49(9):1115-1125. DOI:10.3109/10826084.2014.903753 · 1.23 Impact Factor
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    • "Although pancreatic cancer is difficult to detect in its early stages, several known risk factors exist, with smoking being the most well-documented etiologic agent [2]. Several other risk factors include age, diets high in fat [3], excessive alcohol consumption [4], diabetes mellitus [5], and chronic pancreatitis [6]. Common chemotherapeutic treatments have had little success in improving survival rates or restraining the highly metastatic malignancies [7] with the median survival rate of less than six months and surgical resection as the only effective treatment [8]. "
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    PPAR Research 05/2013; 2013(17):121956. DOI:10.1155/2013/121956 · 1.64 Impact Factor
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    • "Regarding pancreatic cancer (PC), a comprehensive meta-analysis has suggested tobacco smoking, obesity, diabetes mellitus type 2 (DM-2) and chronic pancreatitis as risk factors (5). Alcohol is known to be responsible for 70–80% of all cases of pancreatitis, but it is uncertain if alcohol per se is a risk factor for PC (6,7). Besides the lifestyle factors several inherited disorders, such as HNPCC and Peutz–Jeghers, have been linked with PC (8). "
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