The early growth and development study: using the prospective adoption design to examine genotype-environment interplay. 2008.

Oregon Social Learning Center, 10 Shelton McMurphey Boulevard, Eugene, OR, 97401-4928, USA, .
Behavior Genetics (Impact Factor: 2.84). 04/2010; 40(3):306-14. DOI: 10.1007/s10519-010-9353-1
Source: PubMed

ABSTRACT The Early Growth and Development Study (EGDS) is a prospective adoption design consisting of 360 linked sets of birth parents, adoptive parents, and adopted children followed from 3 months postpartum through child age 7 years and an additional 200 linked sets for whom recruitment is underway. The EGDS brings together the study of genotype-environment correlation and Genotype x Environment (G x E) interaction to inform intervention development by examining mechanisms whereby family processes mediate or moderate the expression of genetic influences. Participants in the EGDS are recruited through domestic adoption agencies located throughout the United States of America. The assessments occur at 6-month intervals until child age 4-(1/2) years and at ages 6 and 7, when the children are in their 1st and 2nd years of formal schooling (kindergarten and first grade). The data collection includes measures of child characteristics, birth and adoptive parent characteristics, adoptive parenting, prenatal exposure to drugs and maternal stress, birth parent and adopted child salivary cortisol reactivity, and DNA from all participants. The preliminary analyses suggest evidence for GxE interaction beginning in infancy. An intervention perspective on future developments in the field of behavioral genetics is described.


Available from: Laura V Scaramella, Jun 02, 2015
1 Follower
  • Source
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Positive family environments are crucial in promoting children's emotional and behavioural well-being, and may also buffer development of attention-deficit/hyperactivity disorder (ADHD). ADHD is highly heritable, but psychosocial factors in the family environment, particularly family cohesion and communication, may mediate genetic predispositions. The purpose of the current study is to examine the mediating influence of the adoptive family environment between pre-adoptive risk factors and youths' ADHD symptomatology at 14 years post adoption. The data used in this study were obtained from the fourth wave of the California Long-Range Adoption Study (CLAS) (n = 449). Using structural equation modelling (SEM), family sense of coherence and family adaptability were tested as possible mediators between environmental and biological predictors and ADHD symptomatology. Predictors included birthweight, gender, age at adoption, adoption from foster care, transracial adoption status, ethnicity and having a previous diagnosis of ADHD. Results show that, while adoption from foster care is negatively associated with family functioning, higher family cohesion and adaptability mediate this influence on children's ADHD symptomatology. Older age of adoption directly predicts greater ADHD symptoms with no mediating influence of the family environment. The mediating influence of the family environment between children's risk factors and ADHD symptoms suggests that family intervention strategies may be helpful in improving adopted children's outcomes. Once children are adopted, targeting family communication patterns and dynamics may be an additional part of developing an evidence-based, post-adoption services toolkit.
    Child Care Health and Development 10/2013; 40(6). DOI:10.1111/cch.12112 · 1.83 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Family theories have been founded on research that cannot discriminate genetic and environmental influences and, consequently, most theories do not have highly developed models of gene–environment interplay in families. Behavioral genetic approaches, which can identify gene–environment interplay, have typically not been driven by family theories and have lacked adequate measurement of family processes. In this article, the authors describe behavioral genetic mechanisms and methods using representative examples of research on family processes, highlighting the advantages of an integrated approach. New directions in research and theory driven by an integrated approach are discussed.
    Journal of Family Theory & Review 03/2014; 6(1). DOI:10.1111/jftr.12028