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Available from: Fred R Hirsch, Jul 04, 2015
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    ABSTRACT: Lung cancer is the leading cause of cancer-related death worldwide, and squamous cell carcinoma is the second most frequent histological subtype. The improvement registered in the last years in the treatment of non-small cell lung cancer is attributable in part to the concept of personalized therapy, and to the possibility to transfer biological discoveries into clinical practice. Major changes have mainly characterized the adenocarcinoma histology, with the detection of the EGFR mutation and the EML4-ALK translocation, targeted by specific tyrosine kinase inhibitors. Despite its interesting oncogenic profile, squamous carcinoma is not the most appropriate example of "druggable disease", as it is characterized by deplorable results, often with a huge toxicity profile and without any benefit in terms of overall survival. At the present time, cytotoxic drugs are still the only treatment options for patients with advanced squamous cell carcinoma. Recent advances in the molecular characterization of squamous carcinoma have identified mutations and alterations, and clinical trials are ongoing to target these changes.
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    ABSTRACT: This paper describes the design of a 4 bit phase shifter GaAs MMIC for operation over a 4-8 GHz bandwidth. Phase shifting is achieved by using GaAs MESFETs to switch the circuit transfer function from high pass to low pass and vice versa. In order to achieve small chip size and improved phase accuracy a novel component has been developed.
    Microwave Conference, 1987. 17th European; 10/1987
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