Dendrimers Designed for Functions: From Physical, Photophysical, and Supramolecular Properties to Applications in Sensing, Catalysis, Molecular Electronics, Photonics, and Nanomedicine

ISM, UMR CNRS No. 5255, Université Bordeaux 1, 33405 Talence Cedex, France.
Chemical Reviews (Impact Factor: 46.57). 03/2010; 110(4):1857-959. DOI: 10.1021/cr900327d
Source: PubMed


A scientific review informed about the functions and applications of dendrimers resulting from supramolecular and physical properties. The review focused on the importance of the purities of dendrimers that potentially varied from one family to the other and significantly influencing the adequate achievement of the functions. It focused on the powerful concepts of dendrimer chemistry in terms of functions and potential applications. The findings revealed that dendrons bonded to polymers were called dendronized polymers and they disclosed properties relevant to those of dendrimers. Branched or hyperbranched polymers were found to be useful alternatives to dendrimers that had significant commercial view and showed closely related properties for functions. Local dendrimer dynamics, such as local motion were also compared to supercooled liquids and linear polymers, including glass transition aspects.

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    • "In solution environments the wide range of tunable properties makes dendrimers a versatile tool as host trough the inclusion of guest molecules in their interior voids or attaching guest molecules in the dendrimers surface [32]. "
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    ABSTRACT: Dendrimers are highly branched macromolecules obtained by stepwise controlled, reaction sequences. The ability to be designed for specific applications makes dendrimers unprecedented components to control the structural organization of matter during the bottom-up synthesis of functional nanostructures. For their applications in the field of biotechnology the determination of dendrimer structural properties as well as the investigation of the specific interaction with guest components are needed. We show how the analysis of the scattering structure factor S(q), in the framework of current models for charged systems in solution, allows for obtaining important information of the interdendrimers electrostatic interaction potential. The finding of the presented results outlines the important role of the dendrimer charge and the solvent conditions in regulating, through the modulation of the electrostatic interaction potential, great part of the main structural properties. This charge interaction has been indicated by many studies as a crucial factor for a wide range of structural processes involving their biomedical application. Due to their easily controllable properties dendrimers can be considered at the crossroad between traditional colloids, associating polymers, and biological systems and represent then an interesting new technological approach and a suitable model system of molecular organization in biochemistry and related fields.
    Biochemistry Research International 02/2014; 2014(2):837651. DOI:10.1155/2014/837651
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    • "Mais à l'heure actuelle, leur utilisation dans la recherche biomédicale connaît un essor particulier. Les dendrimères ont été évalués pour diverses applications biomédicales, notamment comme agents de contraste en imagerie médicale ou comme médicaments [12]. En effet, certains dendrimères possèdent des activités antivirales, antibactériennes ou antitumorales. "
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    ABSTRACT: Les dendrimères sont des macromolécules particulièrement intéressantes pour un très grand nombre d'ap-plications dans des domaines extrêmement variés. Cet intérêt réside essentiellement dans leurs propriétés de coopérativité et de multivalence, ainsi que dans leur très haute capacité d'encapsulation ou de fi xation de petites molécules, et ceci dans un volume de taille nanométrique. Cette caractéristique structurale est la conséquence de leur architecture unique de macromolécules ramifi ées émanant d'un coeur central et possé-dant de nombreuses fonctionnalités périphériques. Les dendrimères sont donc des outils très intéressants pour la délivrance de médicaments et d'acides nucléiques. Dans cet article, les auteurs font un bref rapport de leurs travaux de synthèse de deux familles de dendrimères, les dendrimères poly(amidoamines) et poly(aminoesters), ainsi que de leurs applications pour la délivrance d'acides nucléiques. Mots-clés Dendrimères, poly(amidoamines), poly(aminoesters), délivrance d'acides nucléiques, thérapie génique. Abstract Dendrimers: a powerful tool for nucleic acid delivery Dendrimers have attracted particular attention for drug delivery because of their high drug loading capacity confi ned within a small nanosized volume. This special feature is the result of their unique molecular architecture with cascade branched units emanating from a focal point and numerous end groups on the surface. In this article, the authors will give a brief highlight of their results in the synthesis of poly(amidoamine) and poly(aminoester) dendrimers as well as their application for nucleic acid delivery. Keywords Dendrimers, poly(amidoamine), poly(aminoester), nucleic acid delivery, gene therapy. D epuis quelques années, nous nous intéressons aux
    L'Actualité chimique 01/2014; 381:13. · 0.09 Impact Factor
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    • "The quantity, type, and characteristics of surface terminal groups govern the properties of dendrimers such as aqueous solubility, biocompatibility, and multifunctionality in terms of biomedical and pharmaceutical applications (Shi et al., 2007). The empty interior cavity of dendrimers could be used for physical encapsulation of different guest molecules or small particles (Astruc et al., 2010). Taking advantage of abundant terminal groups, various ligands can be conjugated to the dendrimer periphery via surface engineering, including therapeutic agents, imaging molecules, targeting fragments and other functional moieties. "
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    ABSTRACT: The objectives of this study were to generate novel thermo and pH dual responsive poly(amidoamine) (PAMAM) via precise surface engineering, and investigate the interplay of dendrimer stimuli-responsiveness and the loading and release properties of a model agent, vitamin E acetate (VEAc). A higher dendrimer generation and maximized VEAc loading at elevated pH all contributed to a lower cloud point (CP) of the dendrimer-VEAc complex. The drug loading in G3.5 surface-engineered PAMAM was 22mol/mol (pH 7.0) and 10mol/mol (pH 5.0), which corresponded to a complex CP value at ca. 13(o)C (pH 7.0) and 46(o)C (pH 5.0), respectively. At physiological conditions, only less than 40% of VEAc was liberated when reaching the plateau, whilst more than 90% of VEAc was released from such system within 6h at pH 5.0. This was due to the transition of dendrimer surface from dehydrated state to hydrated state upon pH dropping, enabling rapid drug release for therapeutic action. This smart stimuli-responsive dendritic delivery system holds promise for the efficient drug delivery to tissues with pH abnormality such as tumor.
    International Journal of Pharmaceutics 12/2013; 462(1-2). DOI:10.1016/j.ijpharm.2013.12.031 · 3.65 Impact Factor
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