Dental anomalies in individuals with cleft lip and/or palate.
ABSTRACT Significant heterogeneity has previously been reported but with no consensus on the prevalence of dental anomalies in subjects with a cleft lip and palate (CLP), thus, the purpose of this study was to investigate the frequency of various dental anomalies in the upper dental arch in different cleft groups. Diagnostic records, i.e., panoramic, occlusal and periapical films, dental casts, and intra-oral photographs, of 122 subjects (mean age: 14 +/- 5 years; 67 males and 55 females) were grouped as either unilateral left cleft lip and palate (ULCLP), unilateral right cleft lip and palate (URCLP), bilateral cleft lip and palate (BCLP), or cleft palate (CP). Prevalence rates of 15 different dental anomalies were calculated for each group. Wilcoxon's test was used to determine if there was a statistically significant difference in the number of missing teeth between the right and left sides, in each cleft group. Overall, 96.7 percent of patients were found to have at least one dental anomaly. The most prevalent was agenesis in the anterior region on the cleft side (70.8-97.1 percent). There was a statistically significant difference in the prevalence of agenesis by cleft and non-cleft sides but only in the ULCLP group (P < 0.001). Significantly higher rates of impaction were observed in the anterior and premolar regions in the CLP groups (2.9-29.2 percent), with the highest rates in the anterior region on the cleft sides. A very high proportion of subjects were found to have at least one dental anomaly. Thus, the management of dental anomalies should be central to the treatment planning process of individuals with a cleft.
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ABSTRACT: Failure of corresponding teeth on the right and left sides to form as exact mirror images of each other is an expression of imprecise developmental control. Levels of tooth-size asymmetry can therefore be used to quantify developmental instability in different regions of the dentition. Mesiodistal and buccolingual diameters of deciduous and permanent teeth were measured to the nearest 0.1 mm on serial plaster models of 77 patients with cleft lip with or without a cleft of the palate, and 63 control non-cleft orthodontic patients. In the cleft group as a whole, there were abnormally high levels of tooth-size asymmetry but, although most marked in the upper lateral incisor region, these were neither restricted to the vicinity of the cleft nor to the upper jaw. Thus, in addition to major local disturbances related to the malformation itself, it appears that tooth-size asymmetry results from a generally high level of developmental instability throughout cleft lip/palate dentitions. This generalized developmental instability may be to some extent under genetic control, as cases with positive family histories showed some signs of greater asymmetry than those with negative family histories.Archives of Oral Biology 02/1979; 24(2):141-6. · 1.55 Impact Factor
Article: Genetics of cleft lip and palate.British dental journal 03/1972; 132(3):95-103. · 0.81 Impact Factor
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ABSTRACT: The literature on tooth formation in children with cleft lip and/or palate is reviewed. The main focus of interest is the association of cleft type and dental abnormalities in number, size, shape, timing of formation, and eruption and cause of the abnormalities. The upper lateral incisor is the most susceptible to injury in the area of cleft in both deciduous and permanent dentitions. This tooth is affected in most instances, even in the cases of microforms of the cleft lip. The prevalence of hypodontia increases strongly with the severity of cleft. More teeth are congenitally missing from the upper jaw than from the lower jaw; however, in the permanent dentition both jaws are affected. Very high prevalence of hypodontia are observed in connection with the Van der Woude syndrome associated with cleft and with the Pierre Robin anomaly. Hypodontia is similarly prevalent in subjects with isolated cleft palate with and without a positive family history of clefts. The prevalence of hypodontia varies largely in different populations. Asymmetric formation of the contralateral teeth is a milder form of hypodontia. The prevalence of asymmetrically developing pairs of teeth is far more common in children with clefts than in children with normal palates or lips. In the permanent dentition the timing of tooth formation is delayed in children from all cleft groups compared to noncleft children. The delay lengthens (with increasing severity of cleft) from 0.3 to 0.7 years and is similar in all permanent teeth in both jaws. In children with hypodontia, the delay is still more severe. As the child becomes older, the delay may increase.(ABSTRACT TRUNCATED AT 250 WORDS)American Journal of Orthodontics and Dentofacial Orthopedics 08/1986; 90(1):11-8. · 1.46 Impact Factor