JAMA patient page. Randomized controlled trials.
JAMA The Journal of the American Medical Association (Impact Factor: 30.39). 03/2010; 303(12):1216. DOI: 10.1001/jama.303.12.1216
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ABSTRACT: Analytic studies make it possible to study and verify causal hypotheses and clinical studies, specifically contribute the greatest level of evidence in the verification of these hypothesis. A randomized clinical trial (RCT) is a planned experiment in which two or more preventive, curative or rehabilitating interventions, assigned in an individualized and random way to a group of patients to study the effect of these interventions in man, are compared. To do so, a series of methodological aspects must be taken into account, such as the choice of the subject sample based on adequate screening criteria, random allotment of the subjects to the different intervention groups, choice of the control group, masking or blinding of some or all the subjects participating in the study and description of losses and drop-outs for correct analysis of the data. The characteristics of the type of study, conducted in humans, imply the need for the fulfillment of some ethical and legal requirements that protect the participants, reason why it is essential to obtain an informed consent and favorable report from the Ethics Committee for its conduction.SEMERGEN - Medicina de Familia 06/2007; 33(6):296-304. DOI:10.1016/S1138-3593(07)73899-6
Enfermería Intensiva 07/2008; 19(3). DOI:10.1016/S1130-2399(08)72757-3
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