Article

Plasmodium vivax susceptibility to ferroquine.

Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand.
Antimicrobial Agents and Chemotherapy (impact factor: 4.84). 03/2010; 54(5):2228-30. DOI:10.1128/AAC.01572-09 pp.2228-30
Source: PubMed

ABSTRACT The novel organometallic chloroquine analog ferroquine (SSR 97193) is effective against chloroquine-resistant Plasmodium falciparum. The ex vivo efficacy of ferroquine against Plasmodium vivax isolates was tested. Ferroquine has a potent ex vivo effect on P. vivax schizont maturation (median 50% inhibitory concentration, 15 nM; n = 42). No significant cross-sensitivity between ferroquine and other antimalarials was detected. This drug may be a suitable replacement for chloroquine in the treatment of drug-resistant P. vivax malaria.

0 0
 · 
0 Bookmarks
 · 
34 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

chloroquine-resistant Plasmodium falciparum
 
drug-resistant P. vivax malaria
 
ex vivo efficacy
 
median 50% inhibitory concentration
 
novel organometallic chloroquine analog ferroquine
 
potent ex vivo effect
 
significant cross-sensitivity