The first decade of the National Drug Abuse Treatment Clinical Trials Network: Bridging the gap between research and practice to improve drug abuse treatment

Center for the Clinical Trials Network, National Institute on Drug Abuse, National Institutes of Health, Rockville, MD 20892, USA.
Journal of substance abuse treatment (Impact Factor: 2.9). 06/2010; 38 Suppl 1:S4-13. DOI: 10.1016/j.jsat.2010.01.011
Source: PubMed


The National Institute on Drug Abuse established the National Drug Abuse Treatment Clinical Trials Network (CTN) in 1999 to improve the quality of addiction treatment using science as the vehicle. The network brings providers from community-based drug abuse treatment programs and scientists from university-based research centers together in an alliance that fosters bidirectional communication and collaboration. Collaboration enhanced the relevance of research to practice and facilitated the development and implementation of evidence-based treatments in community practice settings. The CTN's 20 completed trials tested pharmacological, behavioral, and integrated treatment interventions for adolescents and adults; more than 11,000 individuals participated in the trials. This article reviews the rationale for the CTN, describes the translation of its guiding principles into research endeavors, and anticipates the future evolution of clinical research within the Network.

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Available from: Dennis Mccarty, Oct 05, 2015
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    • "We administered the items to an Internet sample of 875 participants from the general population and a clinical sample of 461 patients in treatment for substance use disorders in North Carolina, Oregon, and Pennsylvania. The treatment centers participated in the National Drug Abuse Treatment Clinical Trials Network (McCarty et al., 2008; Tai et al., 2010). The internet sample was collected through YouGov, a web-based polling firm in Palo Alto, CA. "
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    ABSTRACT: Background: Two item banks for substance use were developed as part of the Patient-Reported Outcomes Measurement Information System (PROMIS(®)): severity of substance use and positive appeal of substance use. Methods: Qualitative item analysis (including focus groups, cognitive interviewing, expert review, and item revision) reduced an initial pool of more than 5300 items for substance use to 119 items included in field testing. Items were written in a first-person, past-tense format, with 5 response options reflecting frequency or severity. Both 30-day and 3-month time frames were tested. The calibration sample of 1336 respondents included 875 individuals from the general population (ascertained through an internet panel) and 461 patients from addiction treatment centers participating in the National Drug Abuse Treatment Clinical Trials Network. Results: Final banks of 37 and 18 items were calibrated for severity of substance use and positive appeal of substance use, respectively, using the two-parameter graded response model from item response theory (IRT). Initial calibrations were similar for the 30-day and 3-month time frames, and final calibrations used data combined across the time frames, making the items applicable with either interval. Seven-item static short forms were also developed from each item bank. Conclusions: Test information curves showed that the PROMIS item banks provided substantial information in a broad range of severity, making them suitable for treatment, observational, and epidemiological research in both clinical and community settings.
    Drug and alcohol dependence 10/2015; DOI:10.1016/j.drugalcdep.2015.09.008 · 3.42 Impact Factor
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    • "Federal D&I initiatives have also invested significant financial resources directly toward Gap 1. For instance, NIDA's Clinical Trial Network was created to promote partnerships between researchers and practitioners in order to " validate treatment interventions that fulfill the practical needs of community-based drug abuse treatment programs " (Tai et al., 2010). In the same vein, SAMSHA's ATTCs were formed to enhance the development and training of an addictions workforce able to deliver EBP (Condon, Miner, Balmer, & Pintello, 2008). "
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    ABSTRACT: The overall chasm between those who need treatment for mental health and substance use (M/SU) and those who receive effective treatment consists of two interrelated gaps: the research-to-practice gap and the treatment gap. Prior efforts to disseminate evidence-based practice (EBP) for M/SU have predominantly targeted the research-to-practice gap, by focusing efforts toward treatment providers. This article introduces direct-to-consumer (DTC) marketing that targets patients and caregivers as a complementary approach to existing dissemination efforts. Specific issues discussed include the following: rationale for DTC marketing based on the concept of push versus pull marketing; overview of key stakeholders involved in DTC marketing; and description of the Marketing Mix planning framework. The applicability of these issues to the dissemination of EBP for M/SU is discussed.
    Clinical Psychology Science and Practice 03/2015; 22(1). DOI:10.1111/cpsp.12086 · 2.92 Impact Factor
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    • "The National Drug Abuse Treatment Clinical Trials Network (CTN) tested TES versus treatment as usual in 10 addiction treatment centers. Within the CTN, investigators and community-based treatment providers collaborate to develop, test, and implement new intervention options for patients in alcohol and drug treatment programs (Tai et al, 2010). As part of a multi-trial analysis to study the influence of organizational and workforce characteristics on study outcomes, we assessed attitudes, perceived social norms, and intentions to use web-delivered psychosocial interventions prior to counselor experience with the study intervention. "
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    ABSTRACT: The National Drug Abuse Treatment Clinical Trials Network (CTN) works to bridge the gap between research and practice and tested a Web-delivered psychosocial intervention (the Therapeutic Education System, TES) in 10 community treatment centers. Computer-assisted therapies, such as Web-delivered interventions, may improve the consistency and efficiency of treatment for alcohol and drug use disorders. Prior to the start of the study, we surveyed counselors (N=96) in participating treatment centers and assessed counselor attitudes, perceived social norms and intentions to use a Web-delivered intervention. Analysis of the intention to adopt a Web-delivered intervention assessed the influence of attitudes and perceived social norms. Perceived social norms were a significant contributor to clinician intention to adopt Web-based interventions while attitude was not. To promote successful implementation, it may be helpful to create social norms supportive of computer-assisted therapies.
    Journal of substance abuse treatment 09/2012; 44(4). DOI:10.1016/j.jsat.2012.08.220 · 2.90 Impact Factor
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