Article

Three-year outcomes after kyphoplasty in patients with osteoporosis with painful vertebral fractures.

Department of Medicine I, University of Heidelberg, Heidelberg, Germany.
Journal of vascular and interventional radiology: JVIR (impact factor: 1.81). 03/2010; 21(5):701-9. DOI:10.1016/j.jvir.2010.01.003 pp.701-9
Source: PubMed

ABSTRACT Kyphoplasty immediately improves pain and mobility in patients with painful osteoporotic vertebral fractures, but long-term clinical outcomes are still unclear. This controlled trial evaluates pain, mobility and fracture incidence 3 years after kyphoplasty.
Kyphoplasty was performed in 40 patients with painful osteoporotic vertebral fractures; 20 patients who were selected for kyphoplasty but chose not to undergo the procedure served as controls. All patients received pharmacologic antiosteoporosis treatment, pain medication, and physiotherapy. Pain (visual analog scale of 0-100), mobility (European Vertebral Osteoporosis Study questionnaire score of 0-100), and incident vertebral fractures were assessed at baseline, postprocedurally, and after 12 and 36 months.
Pain score improved after kyphoplasty from 73.8 to 55.9 (immediately after kyphoplasty), 55.6 (12 months), and 54.0 (36 months; P < .001). Pain score in the control group changed from 66.4 to 65.7 at 12 months and 64.0 at 36 months (P = .521). The pain score of the kyphoplasty group was significantly improved versus controls after 36 months (P = .023). Mobility score improved after kyphoplasty from 43.8 to 54.2 (immediately after kyphoplasty), 54.5 (12 months), and 54.8 (36 months; P = .0008) and remained increased (P = .308) compared with controls (39.8 immediately after kyphoplasty, 44.3 at 12 months, and 43.6 at 36 months). The incidence of new vertebral fractures after kyphoplasty was significantly reduced versus controls after 3 years (P = .0341).
Kyphoplasty reduces pain and improves mobility as long as 3 years after the procedure. The long-term risk of new vertebral fractures after kyphoplasty of chronically painful vertebral fractures is reduced versus controls.

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    Article: Balloon kyphoplasty and vertebroplasty in the management of vertebral compression fractures
    S. Boonen, D. A. Wahl, L. Nauroy, M. L. Brandi, M. L. Bouxsein, J. Goldhahn, E. M. Lewiecki, G. P. Lyritis, D. Marsh, K. Obrant, S. Silverman, E. Siris, K. Åkesson, for the CSA Fracture Working Group of the International Osteoporosis Foundation
    [show abstract] [hide abstract]
    ABSTRACT: Vertebral compression fractures (VCFs) are the most prevalent fractures in osteoporotic patients. The classical conservative management of these fractures is through rest, pain medication, bracing and muscle relaxants. The aim of this paper is to review prospective controlled studies comparing the efficacy and safety of minimally invasive techniques for vertebral augmentation, vertebroplasty (VP) and balloon kyphoplasty (BKP), versus non-surgical management (NSM). The Fracture Working Group of the International Osteoporosis Foundation conducted a literature search and developed a review paper on VP and BKP. The results presented for the direct management of osteoporotic VCFs focused on clinical outcomes of these three different procedures, including reduction in pain, improvement of function and mobility, vertebral height restoration and decrease in spinal curvature (kyphosis). Overall, VP and BKP are generally safe procedures that provide quicker pain relief, mobility recovery and in some cases vertebral height restoration than conventional conservative medical treatment, at least in the short term. However, the long-term benefits and safety in terms of risk of subsequent vertebral fractures have not been clearly demonstrated and further prospective randomized studies are needed with standards for reporting. Referral physicians should be aware of VP/BKP and their potential to reduce the health impairment of patients with VCFs. However, VP and BKP are not substitutes for appropriate evaluation and treatment of osteoporosis to reduce the risk of future fractures. KeywordsIOF–Kyphoplasty–Osteoporosis–Pain management–Vertebral fractures–Vertebroplasty
    Osteoporosis International 04/2012; 22(12):2915-2934. · 4.58 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

12 months
 
20 patients
 
3 years
 
36 months
 
40 patients
 
chronically painful vertebral fractures
 
control group
 
European Vertebral Osteoporosis Study questionnaire score
 
fracture incidence 3 years
 
incident vertebral fractures
 
Kyphoplasty
 
kyphoplasty group
 
long-term clinical outcomes
 
long-term risk
 
new vertebral fractures
 
pain medication
 
Pain score
 
painful osteoporotic vertebral fractures
 
pharmacologic antiosteoporosis treatment
 
visual analog scale