Article

Pd/C-mediated synthesis of α-pyrone fused with a five-membered nitrogen heteroaryl ring: a new route to pyrano[4,3-c]pyrazol-4(1H)-ones.

Institute of Science and Technology, JNT University, Kukatpally, Hyderabad 500072, India.
Beilstein Journal of Organic Chemistry (impact factor: 2.52). 01/2009; 5:64. DOI:10.3762/bjoc.5.64 pp.64
Source: PubMed

ABSTRACT Pd/C-mediated alkynylation of 5-iodo-pyrazole-4-carboxylic acid, involving the first regioselective construction of α-pyrone ring on a pyrazol moiety via tandem coupling-cyclization process, has been developed to afford pyrano[4,3-c]pyrazol-4(1H)-one in a single pot.

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Keywords

5-iodo-pyrazole-4-carboxylic acid
 
single pot
 
α-pyrone ring