Article

Intranodal palisaded myofibroblastoma (intranodal hemorrhagic spindle cell tumor with amianthoid fibers): a case report and literature review

Diagnostic Pathology 01/2010; DOI:http://www.doaj.org/doaj?func=openurl&genre=article&issn=17461596&date=2010&volume=5&issue=1&spage=12
Source: DOAJ

ABSTRACT Abstract

Intranodal palisaded myofibroblastoma (IPM) is a benign mesenchymal neoplasm originating from smooth muscle cells and myofibroblasts. It is characterized by spindle cells, amianthoid fibers, and by the proliferation of hemosiderin-containing histiocytes in the lymph node. A nodular lesion was excised from the inguinal region of an 80-year-old male patient. Macroscopic examination of a section of the lesion demonstrated a solid appearance with hemorrhagic areas. Microscopic examination revealed spindle cell proliferation, amianthoid fibers, hemosiderin pigment, and extravasated erythrocytes. Nuclei of the spindle cells displayed a palisaded appearance. Compressed lymphoid tissue was observed around the lesion. With Masson's trichrome, spindle cells stained as smooth muscle, whereas collagen staining was observed in homogeneous eosinophilic accumulations. Neoplastic cells were identified by the presence of vimentin and SMA. The Ki67 index was less than 1%. In light of these results, the case was diagnosed as "intranodal palisaded myofibroblastoma." IPM is an uncommon neoplasm originating from the stromal component of the lymph node. Although IPM is benign, it is frequently confused with metastatic lesions.

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    Article: Intranodal palisaded myofibroblastoma originating from retroperitoneum: an unusual origin.
    Jayesh Sagar, Athanasia Vargiamidou, Hemachandran Manikkapurath
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    ABSTRACT: Intranodal palisaded myofibroblastoma is one of the primary mesenchymal tumours. The inguinal region is the commonest site of this rare tumour. As there are only about 55 such cases reported in the literature, the precise aetiology and pathogenesis have yet to be explained adequately. Here we report a case of a 72 year old man presented with incidental finding of intranodal palisaded myofibroblastoma in the retroperitoneal region. A 72-year old man presented with abdominal pain in right upper quadrant with an incidental finding of abdominal mass in the right flank. The computerised tomogram scan of abdomen confirmed acute cholecystitis with a 5 x 5 cm retroperitoneal mass. He underwent cholecystectomy with excision of this mass. He recovered well following his operation and was discharged from the hospital. Histological examination confirmed the diagnosis of intranodal palisaded myofibroblastoma. To our knowledge, this is the first case of intranodal palisaded myofibroblastoma originating from retroperitoneum. Along with the rarity of this case, we also discussed its typical histopathological findings, aetiology and pathogenesis.
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    Diagnostic Pathology 12/2011; 6:120. · 1.64 Impact Factor
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Keywords

80-year-old male patient
 
benign mesenchymal neoplasm originating
 
Compressed lymphoid tissue
 
extravasated erythrocytes
 
hemorrhagic areas
 
hemosiderin-containing histiocytes
 
homogeneous eosinophilic accumulations
 
intranodal palisaded myofibroblastoma
 
lymph node
 
Macroscopic examination
 
Masson's trichrome
 
metastatic lesions
 
Microscopic examination
 
Neoplastic cells
 
smooth muscle
 
smooth muscle cells
 
solid appearance
 
spindle cell proliferation
 
spindle cells
 
spindle cells stained