Conference Paper

A 60 days BedRest study: Preliminary QUS BUA changes at the calcaneus site

DOI: 10.1109/ULTSYM.2005.1603273 Conference: Ultrasonics Symposium, 2005 IEEE, Volume: 4
Source: IEEE Xplore


A 60 days bed rest study has been organized in the Benjamin Franklin Universitätkliniküm in Berlin by the Professor Felsenberg and Dr Rittweger, under ESA requirements. It consists in simulating microgravity effects on body physiology, by lying horizontally in bed for 60 days. We have participated to that study in order to evaluate the bone changes at the heel site using the Beam Scanner device. 16 young, healthy males (volunteers), aged from 20 to 45 years old, were included in the QUS (Quantitative UltraSound) protocol. Three QUS acquisitions were performed on each foot with interim repositioning. Measurement sessions were planned before bed rest, every 15 days during the Bedrest, and after 1, 3, 6 and 12 months. The subjects were divided in two groups: a control group and an exercise group. The exercise training session was essentially concerning the lower limbs and feet. We clearly have a difference in bone loss between these two groups. The control group bone loss has been estimated superior to 6% for the BUA parameter and is statistically highly significant. The bone loss difference between groups is also statistically significant. Similar results have been obtained with the SOS parameter. However this parameter is more sensitive to soft-tissues thickness changes and deeper analysis is in progress. In conclusion it was the first time that a QUS device was used in the context of such a longitudinal bone changes study. Two months bedrest are long enough to provide changes at the lower limbs and it has been demonstrated that QUS measurements are well adapted to follow bone changes over such a period.

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