Article

The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors.

Department of Chemistry, Innovative Technnology Centre, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Organic & Biomolecular Chemistry (impact factor: 3.7). 04/2010; 8(7):1588-95. DOI:10.1039/b924309g pp.1588-95
Source: PubMed

ABSTRACT The continuous flow synthesis of butane-2,3-diacetal protected derivatives has been achieved using commercially available flow chemistry microreactors in concert with solid supported reagents and scavengers to provide in-line purification systems. The BDA protected products are all obtained in superior yield to the corresponding batch processes.

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Keywords

BDA
 
butane-2,3-diacetal
 
commercially available flow chemistry microreactors
 
in-line purification systems
 
solid
 
superior yield