Synthesis and Biological Evaluation of 7-O-Modified Formononetin Derivatives

Research Letters in Organic Chemistry 01/2008; 2008(1687-6865). DOI: 10.1155/2008/209830
Source: OAI

ABSTRACT Three series of novel formononetin derivatives were synthesized, in which formononetin and
heterocyclic moieties were separated by 2-carbon, 3-carbon, and 4-carbon spacers. The chemical
structures of these compounds were confirmed. All the derivatives were screened for antiproliferative
activities against Jurkat cell line and HepG-2 cell line. In this paper, compounds prepared were also
screened for their antibacterial activity of six bacterial strains. Compound
3b exihibited promising
antibacterial activity against B. subtilis with minimal inhibitory concentration (MIC) value of 0.78 𝜇g/mL, and compound 5e showed significant antiproliferative activities against Jurkat cell growth
with IC50 of 1.35×10−4 𝜇g/mL. The preliminary investigation of structure-activity relationships (SARs)
was also discussed based on the obtained experimental data.

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