Article

The Child Is Father to the Man: Developmental Roles for Proteins of Importance for Neurodegenerative Disease

University of Rochester, Rochester, New York, United States
Annals of Neurology (Impact Factor: 11.91). 02/2010; 67(2):151-8. DOI: 10.1002/ana.21841
Source: PubMed

ABSTRACT Although Alzheimer's and Parkinson's diseases predominately affect elderly adults, the proteins that play a role in the pathogenesis of these diseases are expressed throughout life. In fact, many of the proteins hypothesized to be important in the progression of neurodegeneration play direct or indirect roles in the development of the central nervous system. The systems affected by these proteins include neural stem cell fate decisions, neuronal differentiation, cellular migration, protection from oxidative stress, and programmed cell death. Insights into the developmental roles of these proteins may ultimately impact the understanding of neurodegenerative diseases and lead to the discovery of novel treatments.

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