Efficacy of a meal replacement diet plan compared to a food-based diet plan after a period of weight loss and weight maintenance: a randomized controlled trial

Research & Development, Medifast, Inc, Owings Mills, Maryland, USA.
Nutrition Journal (Impact Factor: 2.6). 03/2010; 9(1):11. DOI: 10.1186/1475-2891-9-11
Source: PubMed


Obesity has reached epidemic proportions in the United States. It is implicated in the development of a variety of chronic disease states and is associated with increased levels of inflammation and oxidative stress. The objective of this study is to examine the effect of Medifast's meal replacement program (MD) on body weight, body composition, and biomarkers of inflammation and oxidative stress among obese individuals following a period of weight loss and weight maintenance compared to a an isocaloric, food-based diet (FB).
This 40-week randomized, controlled clinical trial included 90 obese adults with a body mass index (BMI) between 30 and 50 kg/m2, randomly assigned to one of two weight loss programs for 16 weeks and then followed for a 24-week period of weight maintenance. The dietary interventions consisted of Medifast's meal replacement program for weight loss and weight maintenance, or a self-selected, isocaloric, food-based meal plan.
Weight loss at 16 weeks was significantly better in the Medifast group (MD) versus the food-based group (FB) (12.3% vs. 6.9%), and while significantly more weight was regained during weight maintenance on MD versus FB, overall greater weight loss was achieved on MD versus FB. Significantly more of the MD participants lost >or= 5% of their initial weight at week 16 (93% vs. 55%) and week 40 (62% vs. 30%). There was no difference in satiety observed between the two groups during the weight loss phase. Significant improvements in body composition were also observed in MD participants compared to FB at week 16 and week 40. At week 40, both groups experienced improvements in biochemical outcomes and other clinical indicators.
Our data suggest that the meal replacement diet plan evaluated was an effective strategy for producing robust initial weight loss and for achieving improvements in a number of health-related parameters during weight maintenance, including inflammation and oxidative stress, two key factors more recently shown to underlie our most common chronic diseases. NCT01011491.

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Article: Efficacy of a meal replacement diet plan compared to a food-based diet plan after a period of weight loss and weight maintenance: a randomized controlled trial

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    • "Randomized clinical trial Ninety-two 19-70-year- old adults Very low energy diet (VLED) Structured meal plan combined with either two meal replacements or orlistat plus physical activity (6 months) Weight, body composition no signifi cant difference in weight alteration between groups in weight maintenance period Davis, 2010, the US [15] Randomized controlled trial "
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    ABSTRACT: Background: Weight regain after weight loss is a common problem for all those obese or overweight who have had a recent weight loss. Different cures such as diet therapy, behavioral therapy, exercise or a mixture of them have been advised as solutions. The purpose of this review is to find the best diet or eating pattern to maintain a recent weight loss. Materials and Methods: We searched in PubMed and SCOPUS by using the following key words: Overweight, obesity, weight maintenance, weight regain, and diet therapy. Finally, we assessed 26 articles in the present article. Results: Meal replacement, low carbohydrate-low glycemic index (GI) diet, high protein intake, and moderate fat consumption have shown some positive effects on weight maintenance. However, the results are controversial. A Dietary Approach to Stop Hypertension (DASH)-type diet seems helpful for weight maintenance although the need for more study has remained. Some special behaviors were associated with less weight regain, such as, not being awake late at night, drinking lower amount of sugar-sweetened beverages, and following a healthy pattern. Some special foods have been suggested for weight maintenance. However, the roles of specific foods are not confirmed. Conclusion: Healthy diets recommend low carbohydrate, low GI, and moderate fat foods, but it is not clear whether they are useful in preventing weight gain. It seems that consuming fewer calories helps people to keep weight loss. Further research to find strategies in obesity management focusing on successful maintenance of weight loss is needed.
    Journal of research in medical sciences 03/2014; 19(3):268-275. · 0.65 Impact Factor
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    • "This magnitude of decreasing AC was exceeded at all time points, highlighting the potential clinical benefit for MWCC clients. These results are consistent with previous findings obtained by the MD plan versus an isocaloric control group [15]. In that study, reductions in markers of inflammation and oxidative stress, two known risk factors for cardiovascular disease and cancer [44], were also found. "
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    ABSTRACT: Objective: A chart review was performed to evaluate the effectiveness of the Medifast (MD) meal replacement (MR) plan in a Medifast Weight Control Center (MWCC) on body weight, body composition, and other health measures at 4, 12, 24 weeks, and final weight loss visit. Methods: Charts included adults aged 18 -70 (n = 446) with a BMI ≥ 25 kg/m 2 who attended one of three MWCCs and were following the MD MR program. Data were collected electronically and included weight, systolic and diastolic blood pressure, pulse, lean muscle mass (LMM), body fat mass, % body fat, and abdominal circumference. Compliance measures included attendance at weekly visits, intake of MRs and supple-ments, food journals, and ketone testing. Results: Significant weight loss and % weight loss were achieved at all time points with clinically significant weight loss (>5%) occurring in just 4 weeks. Additionally, significant improvements in body composition were seen at all time points coupled with increases in % total body weight as LMM (% LMM im-proved by 3.5, 9.8, 16.0, and 13.9%, respectively). Blood pressure and pulse were significantly improved, demonstrat-ing the clinical benefit for clients. Multivariate regression revealed a strong inverse relationship between weight change, % compliance with attendance, and the number of weeks that MRs were taken as recommended as well as a positive association with number of ketone tests. Conclusion: The MD MR plan, combined with the support and accountability available in the MWCC, is an efficacious program that promotes significant weight loss and improvements in body composition. These results reveal significant associations between components of compliance and weight loss, but par-ticularly highlight the importance of attendance, a focus of the MWCC model compared to non-clinic models.
    Food and Nutrition Sciences 10/2012; 3(10):1433-1444. DOI:10.4236/fns.2012.310187
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    • "A validated satiety score numerical scale was used according to the method of Haber et al [23] on the basis of a scoring system with grades from −10 cm (extreme hunger) to 10 cm (extreme satiety) VAS. VAS are often used to measure subjective appetite sensations and the validity and reproducibility have been shown in several studies [23] [24]. Subjects were instructed to rate themselves by marking the scale at the point that was most appropriate to their feeling at that time. "
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    ABSTRACT: Background: The high protein (HP) breakfast reduced gastric emptying and the most satiat-ing macronutrient appears to be dietary protein. Few studies have investigated the effects of protein to energy ratio in breakfast on mood, alertness and attention. Objective: This study was designed to investigate whether the HP breakfast is more beneficial to mood, alertness and attention of the healthy undergraduate student than adequate-protein (AP) breakfast through the rising body temperature and re-maining stable blood glucose or through other physiologic processes. Methods: Thirteen healthy male undergraduate students (18 -23 y) were studied in a double-blind, randomized crossover design. Blood samples, body tem-perature, satiety, mood and Continuous Per-formance Test (CPT) were assessed after the consumption of two isocaloric breakfasts that differed in their protein and carbohydrate con-tent: an HP breakfast (50%, 30%, and 20% of energy from protein, carbohydrate, and fat, re-spectively) or an AP breakfast (10%, 70%, and 20% of energy from protein, carbohydrate, and fat, respectively). Results: Consumption of an HP breakfast resulted in more steady glucose and insulin than AP breakfast consumption (p < 0.05). Satiety scores and body temperature were higher after HP breakfast consumption (p < 0.05). And most important, the positive mood and CPT scores were higher after HP breakfast than after AP breakfast intake (p < 0.05). Conclusion: HP breakfast can effectively stabilize postprandial serum glucose concentration and elevate post-prandial temperature of healthy male under-graduate students. Our present findings dem-onstrate the relationship between HP breakfast and mood, alertness and attention. This study indicated that HP breakfast may enhance human performance probably by increasing the thermic effect of a food and elevating body temperature.
    Health 01/2011; 03(06). DOI:10.4236/health.2011.36065 · 0.51 Impact Factor
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