May Toxoplasma gondii increase suicide attempt-preliminary results in Turkish subjects?
ABSTRACT Suicide attempts are one of the risk factors of suicide. Possible mechanisms by which Toxoplasma gondii may affect human behavior and it may also cause humans to attempt suicide. The aim of this study is to find out whether or not T. gondii is one of the reasons in suicide attempts. We investigated the sero-positivity level for anti-Toxoplasma IgG and IgM antibodies by enzyme-linked immunosorbent assay in subjects who have attempted to suicide to find out whether there is a probable relationship between T. gondii and suicide attempts. In our study, we selected 200 cases of suicide attempts and 200 healthy volunteers. The sero-positivity level for anti-Toxoplasma IgG antibodies among suicide attempts (41%) was significantly higher than the control group (28%). This signifies that there might be a causal relationship between toxoplasmosis and the etiology of suicide attempt.
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- "Otherwise, associations between asthma and increased SI and suicide attempts were reported among adults in the community , and young people hospitalized for asthma (Goodwin and Eaton 2005; Goodwin et al. 2005). Strong evidence of an association between T. gondii and SB (Okusaga and Postolache 2012) was also unveiled in cross-sectional studies (Arling et al. 2009; Yagmur et al. 2010; Ling et al. 2011; Okusaga et al. 2011; Zhang et al. 2012). A prospective cohort study on 45 788 women showed a predictive association between T. gondii IgG antibody levels and selfdirected violence, violent suicide attempts, and suicide in later life (Pedersen et al. 2012). "
ABSTRACT: Suicidal behaviour (SB) entered the DSM-5, underlying a specific biological vulnerability. Then, recent findings suggested a possible role of the immune system in SB pathogenesis. The objective of this review is to present these main immune factors involved in SB pathogenesis. We conducted a review using Preferred Reporting Items for Systematic reviews and Meta-Analysis criteria, and combined ("Inflammation") AND ("Suicidal ideation" OR "Suicidal attempt" OR "suicide"). Post mortem studies demonstrated associations between suicide and inflammatory cytokines in the orbitofrontal cortex, a brain region involved in suicidal vulnerability. Also, microgliosis and monocyte-macrophage system activation may be a useful marker of suicide neurobiology. Kynurenine may influence inflammatory processes, and related molecular pathways may be involved in SB pathophysiology. Few recent studies associated inflammatory markers with suicidal vulnerability: serotonin dysfunction, impulsivity and childhood trauma. Interestingly, the perception of threat that leads suicidal individuals to contemplate suicide may activate biological stress responses, including inflammatory responses. Translational projects would be crucial to identify a specific marker in SB disorders, to investigate its clinical correlations, and the interaction between inflammatory cytokines and monoamine systems in SB. These researches might lead to new biomarkers and novel directions for therapeutic strategies.The World Journal of Biological Psychiatry 07/2015; DOI:10.3109/15622975.2015.1054879 · 4.23 Impact Factor
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ABSTRACT: A three-axis tension sensor for a tethered satellite system is modeled and simulated. The design uses an aluminum cross fixed at each end with a rod mounted at the center. Semiconductor strain gauge bridges mounted on the cross resolve the tether tension into three orthogonal components. The model incorporates the effects of temperature on the strain gauges. The response of the sensor to a range of temperatures and tensions is simulated, and a method of thermal compensation is proposedSystem Theory, 1990., Twenty-Second Southeastern Symposium on; 04/1990
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ABSTRACT: Toxocara canis, the common intestinal nematode of dogs and foxes, is the parasite responsible for human toxocarosis. It has recently been shown that dogs may harbour eggs of the parasite in their fur. To further investigate this claim a population of 100 stray dogs was examined to establish the prevalence and intensity of adult toxocaral worm infection in the intestines and eggs harboured in the hair. A novel method of washing the eggs from the hair was used. Sixty-seven percent of dogs were found to have T. canis eggs on their hair with a mean egg retrieval of nearly 584 eggs per gram from positive dogs. The age of the dog was found to be the only significant factor to influence the prevalence and intensity of eggs, with 95% of all the eggs recovered found on puppies. Thirty-nine percent of dogs were found to have adult T. canis worms in their intestine, although a significantly higher percentage of puppies (80%) were infected with worms than adults (22.5%). Puppies also had more worms per infection than adults and have a strong positive correlation between egg and worms numbers whereas adults did not. These studies show that stray dogs, particularly puppies, potentially harbour considerable numbers of eggs on their hair, at densities far higher than those reported in the soil or the general environment.Veterinary Parasitology 04/2008; 152(1-2):85-93. DOI:10.1016/j.vetpar.2007.12.008 · 2.55 Impact Factor