Study of hypothermia therapy after pediatric cardiac arrest.
Children's Hospital of Eastern Ontario, Ottawa, ON, Canada (Doherty) The Hospital for Sick Children, Toronto, ON, Canada (Hutchison).Pediatric Critical Care Medicine (impact factor: 3.13). 03/2010; 11(2):315-6; author reply 316-7. DOI:10.1097/PCC.0b013e3181cbddb0 pp.315-6; author reply 316-7
Canadian Medical Association Journal 06/2012; 184(11):1257-64. · 8.22 Impact Factor
An Pediatr (Barc). 02/2012; 76(2):98-102.
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ABSTRACT: Introduction: Therapeutic hypothermia (TH) improves neurological outcome in adults after ven-tricular fibrillation cardiac arrest and in neonates with hypoxic ischemic encephalopathy. The effect of TH in children is under investigation. Objectives: To assess the feasibility, efficacy and safety of a pilot program of TH in pediatric cardiac arrest.Material and methods: Prospective study in a pediatric intensive care unit. An external coolingmethod with a servo system was used on all patients according to an established protocol. Values expressed as median (IQ range). Results: Six patients were included, of whom 5 had an out of hospital cardiac arrest. The mean age was 33 months (16-120) and Glasgow coma scale 6 (4-7). The T◦ prior to the induction of TH was 39.2◦ C (39.1-39.4). The median T◦ used was 34.0◦ C (33.5-34.8◦ C), which was reached in 4 h. (3-7) after the start and maintained for 48 h. (45-54). The rewarming was carried out over a period of 14 h. (12-16). Hypokalemia was the most common adverse event found. Five patients survived to hospital discharge with a Glasgow Coma Scale of 13 (11-14). At 6 months follow up the Pediatric Cerebral Performance Category score was ≤ 2 in three patients. Conclusion: In this pilot study, the use of mild therapeutic hypothermia with a protocol that included rapid sequence induction with an external surface cooling technique was feasible, effective and safe in children with cardiac arrest.Anales de Pediatría 01/2012; 76(2):98-102. · 0.77 Impact Factor
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