Serum markers may distinguish biliary atresia from other forms of neonatal cholestasis

Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Journal of pediatric gastroenterology and nutrition (Impact Factor: 2.63). 02/2010; 50(4):411-6. DOI: 10.1097/MPG.0b013e3181cb42ee
Source: PubMed


Biliary atresia (BA) is the most serious liver disease in infants. Diagnosis currently depends on surgical exploration of the biliary tree. Noninvasive tests that distinguish BA from other types of neonatal liver disease are not available.
To identify potential serum biomarkers that classify children with neonatal cholestasis, we performed 2-dimensional difference gel electrophoresis, statistical analysis, and tandem mass spectrometry using serum samples from 19 infants with BA and 19 infants with non-BA neonatal cholestasis.
Eleven potential serum biomarkers were found that could in combination classify children with neonatal cholestasis.
Although no single biomarker or imaging test adequately distinguishes BA from other types of neonatal cholestasis, combinations of biomarkers, imaging tests, and noninvasive clinical criteria should be further explored as potential tests for rapid and accurate diagnosis of BA.

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Available from: Robert Heuckeroth, Oct 31, 2014
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