Article

Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives.

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India.
European journal of medicinal chemistry (impact factor: 3.27). 02/2010; 45(6):2467-72. DOI:10.1016/j.ejmech.2010.02.031
Source: PubMed

ABSTRACT A number of N-(4,6-substituted diphenylpyrimidin-2-yl) semicarbazones (4a-t) were synthesized and tested for their anticonvulsant activity against the two seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ). All the synthesized compounds possessed the four essential pharmacophoric elements for good anticonvulsant activity. Most of the compounds displayed good anticonvulsant activity with lesser neurotoxicity. To assess the unwanted effects of the compounds on liver, estimation of enzymes and proteins was carried out.

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Keywords

4a-t
 
anticonvulsant activity
 
estimation
 
four essential pharmacophoric elements
 
good anticonvulsant activity
 
lesser neurotoxicity
 
maximal electroshock seizure
 
subcutaneous pentylenetetrazole
 
two seizure models
 
unwanted effects