Clinical performance of different care systems with silicone hydrogel contact lenses

Centre for Contact Lens Research, School of Optometry, University of Waterloo, 200 University Ave. West, Waterloo, ON N2L3G1, Canada.
Contact lens & anterior eye: the journal of the British Contact Lens Association (Impact Factor: 1.37). 03/2010; 33(4):189-95. DOI: 10.1016/j.clae.2010.01.006
Source: PubMed


To assess the clinical and subjective performance of a one-step hydrogen peroxide (H2O2) lens care system compared to a multi-purpose disinfecting system (MPDS) when used with silicone hydrogel (SiH) lenses.
This was an eight-week, contralateral (lens type) clinical trial with a randomized, cross-over (care system) design. The H2O2 system was Clear Care ((AO Sept Plus) CIBA VISION) and the MPDS was OPTI-FREE RepleniSH (Alcon) and the SiH materials were lotrafilcon B (Air Optix; CIBA VISION) and senofilcon A (Acuvue OASYS, Johnson & Johnson Vision Care). Investigators and subjects were masked to lens care and lens type, respectively. Clinical variables and ocular health assessments were conducted at a baseline, two-week and four-week visit for each cross-over phase. Comfort, dryness and vision were rated on 0-100 scales. Wearing times and comfortable wearing times were also recorded.
Twenty-six subjects were enrolled: nine male, 17 female, mean age (+/-standard deviation) 31+/-12 years (range 17-59 years) and 24 subjects completed the study. Clinical variables showed no difference between solutions (all p > 0.05), however one subject exhibited solution-induced corneal staining with both lens materials and the MPDS. There was no difference between solutions in subjective overall ratings of comfort, dryness or vision (p > 0.05). The H2O2 resulted in longer reported comfortable wearing times than the MPDS (10.93 +/- 1.71 vs 9.84 +/- 1.47 h; repeated measures ANOVA, p < 0.01).
While both lens care systems performed well with the SiH lenses used, the H2O2 resulted in a longer reported comfortable wearing time then the MPDS.

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    • "Consequently, a large number of studies have examined the influence of lens care systems on the performance of silicone hydrogel contact lenses. However, whereas most studies have assessed the effect of lens care on comfort [1] [2] [3] [4] [5], very few studies have quantified the effect of lens care on lipid deposits or on-eye contact lens wettability, which are other relevant clinical endpoints [6] [7] [8]. Nichols studied the effect of four lens care systems on lipid deposition with galyfilcon A silicone hydrogel contact lenses and concluded that whereas small differences between lens care systems existed, the main factor that affected lipid deposits was the incorporation of a digital rub in the lens care regimen [7]. "
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