Weakness after foreign travel in a 40-year-old man.
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ABSTRACT: Guillain-Barré syndrome (GBS) is often triggered by a preceding bacterial or viral infection. Occasionally, it has been observed in association with acute hepatitis A, B and C, and three cases have been previously described in India in which GBS was associated with acute hepatitis E. A molecular mimicry mechanism is supposed to be involved in the pathogenesis of GBS triggered by infectious agents, although the nature of the shared epitopes has not been characterized in most instances, including that in the case of hepatotropic viruses. We report a case of GBS following acute hepatitis E in a European individual. The presence of antiganglioside GM2 antibodies in this patient suggested molecular mimicry involving ganglioside GM2 in the pathogenesis of GBS associated with hepatitis E.World Journal of Gastroenterology 05/2009; 15(13):1645-7. · 2.55 Impact Factor
Article: [GUILLAIN-BARR'E SYNDROME].Duodecim; lääketieteellinen aikakauskirja 02/1964; 80:405-11.
Article: [Guillain-Barré syndrome].Anales espanoles de pediatria 11/1992; 37(4):333-4.
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Weakness after foreign travel in a 40-year-old man
Gabrielle C. Colleran & Martin J. Shelly &
Michael R. Moynagh & Eoin C. Kavanagh
Published online: 2 March 2010
# ISS 2010
A 40-year-old man presented with increasing lethargy,
malaise, fever and sweating, which were associated with
tingling and altered sensation beginning in his distal
extremities, toes and fingers, before spreading proximally,
ultimately resulting in an inability to bear weight. These
symptoms followed a mild flu-like illness and recent
foreign travel (Fig. 1).
Fig. 1 a Sagittal T1-weighted
MRI of the lumbar spine. The
arrow points to the lumbar
nerve roots. b T1-weighted MRI
of the lumbar spine following
administration of gadolinium
The diagnosis can be found at doi:10.1007/s00256-010-0906-4
G. C. Colleran (*):M. J. Shelly:M. R. Moynagh:E. C. Kavanagh
Department of Radiology, Mater Misericordiae University
Dublin 7, Ireland
Skeletal Radiol (2010) 39:815