An old dog learns new tricks: A novel function for Cdc20-APC in dendrite morphogenesis in neurons

Department of Pathology, Harvard Medical School, Boston, MA USA.
Cell cycle (Georgetown, Tex.) (Impact Factor: 4.57). 02/2010; 9(3):482-5. DOI: 10.4161/cc.9.3.10558
Source: PubMed

ABSTRACT The E3 ubiquitin ligases Cdc20-anaphase-promoting complex (Cdc20-APC) and Cdh1-APC play key roles in cell cycle transitions in proliferating cells. Remarkably, these ubiquitin ligases are also expressed in postmitotic neurons, raising interest in non-mitotic functions of the APC. Cdh1-APC has been implicated in diverse functions in the nervous system, from the control of axon growth and patterning to synapse development to neuron survival. However, until recently the question of whether Cdc20-APC harbors functions in neurons remained unanswered. New evidence from Kim et al. (2009) has uncovered a novel role for Cdc20-APCin dendrite growth and elaboration in post-mitotic neurons. Interestingly, the histone deacetylase HDAC6 augments Cdc20-APC activity at the centrosome by promoting Cdc20 polyubiquitination. In turn, Cdc20-APC triggers the degradation of the centrosomally localized protein Id1 and thereby promotes dendrite growth and elaboration. These findings have advanced our understanding of APC biology in neuronal connectivity in the brain.

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Available from: Albert H Kim, Sep 29, 2015
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    • "Besides, Cdc20-APC triggers the degradation of the transcription factor NeuroD2 and thereby promotes presynaptic differentiation [22]. Usually, Cdh1–APC is active during late mitotic and G1 phase of the cell cycle, whereas Cdc20-APC drives the anaphase in the early stage of mitosis [23] [24] [25] [26]. Both Cdh1–APC and Cdc20– APC appear to control distinct temporal phases of axon differentiation in postmitotic neurons in the CNS thus demonstrating their specific regulation of different phases of neuronal maturation: Cdh1–APC seems to predominate the early phase of axon development to control axon growth and patterning, while Cdc20–APC acts at a later stage of axon development to promote presynaptic axonal morphogenesis [27]. "
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