Article

Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosis

Melbourne Neuropsychiatry Centre, c/o National Neuroscience Facility, 161 Barry Street, Carlton South, Victoria 3053, Australia. .
The British journal of psychiatry: the journal of mental science (Impact Factor: 7.34). 03/2010; 196(3):206-11. DOI: 10.1192/bjp.bp.109.069732
Source: PubMed

ABSTRACT Morphological abnormalities of the superior temporal gyrus have been consistently reported in schizophrenia, but the timing of their occurrence remains unclear.
To determine whether individuals exhibit superior temporal gyral changes before the onset of psychosis.
We used magnetic resonance imaging to examine grey matter volumes of the superior temporal gyrus and its subregions (planum polare, Heschl's gyrus, planum temporale, and rostral and caudal regions) in 97 antipsychotic-naive individuals at ultra-high risk of psychosis, of whom 31 subsequently developed psychosis and 66 did not, and 42 controls.
Those at risk of psychosis had significantly smaller superior temporal gyri at baseline compared with controls bilaterally, without any prominent subregional effect; however, there was no difference between those who did and did not subsequently develop psychosis.
Our findings indicate that grey matter reductions of the superior temporal gyrus are present before psychosis onset, and are not due to medication, but these baseline changes are not predictive of transition to psychosis.

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    • "Research in younger relatives has also highlighted the superior temporal gyrus as an important region with reduced volume of both the right and left superior temporal gyrus on ROI tracing (Rajarethinam et al., 2004). Findings consistent with this have also been demonstrated in those at high clinical risk for developing schizophrenia (Crossley et al., 2009; Fusar-Poli et al., 2011b), including abnormalities in the planum temporale (Takahashi et al., 2010). Subjects with an established diagnosis of schizophrenia have also shown functional and structural abnormalities in this region, suggesting this area is important in those who are considered to be at familial high risk, those considered to be at clinical high risk and those with schizophrenia (Gur et al., 2007; Crossley et al., 2009; Nejad et al., 2011). "
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