Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosis.
ABSTRACT Morphological abnormalities of the superior temporal gyrus have been consistently reported in schizophrenia, but the timing of their occurrence remains unclear.
To determine whether individuals exhibit superior temporal gyral changes before the onset of psychosis.
We used magnetic resonance imaging to examine grey matter volumes of the superior temporal gyrus and its subregions (planum polare, Heschl's gyrus, planum temporale, and rostral and caudal regions) in 97 antipsychotic-naive individuals at ultra-high risk of psychosis, of whom 31 subsequently developed psychosis and 66 did not, and 42 controls.
Those at risk of psychosis had significantly smaller superior temporal gyri at baseline compared with controls bilaterally, without any prominent subregional effect; however, there was no difference between those who did and did not subsequently develop psychosis.
Our findings indicate that grey matter reductions of the superior temporal gyrus are present before psychosis onset, and are not due to medication, but these baseline changes are not predictive of transition to psychosis.
SourceAvailable from: Fernando Lázaro Perlado[Show abstract] [Hide abstract]
ABSTRACT: Las psicosis de la epilepsia: presentación de un caso clínico y revisión de la literatura. The psychosis of epilepsy: a case report and literature review. Recibido: 13/08/2012; aceptado con modificaciones: 17/12/2012 RESUMEN: Presentamos el caso de un varón de 72 años con un diagnóstico previo de epilepsia del lóbu-lo temporal y esquizofrenia paranoide, que mostraba episodios de psicosis con sintomatología pleomórfica y atípica que no respondía bien al tratamiento anti-psicótico. El paciente no presentaba un deterioro en su personalidad y había demostrado un buen ajuste y funcionamiento social. Tras revisar el caso se llega a cuestionar el diagnóstico previo de esquizofrenia paranoide proponiendo el diagnóstico alternativo de epilepsia del lóbulo temporal: crisis comiciales con sintomatología psicótica. Se instaura el tratamiento adecuado con éxito lo que permite el alta del paciente a su domicilio. Revisamos la literatura en la materia, concluyendo que las psicosis de la epilepsia han de tenerse en cuenta en casos de psicosis atípicas, resis-tentes a tratamiento en personas con buen funciona-miento psico-social sin deterioro en su personalidad. PALABRAS CLAVE: epilepsia del lóbulo temporal; psicosis comiciales; psicosis de la epilepsia; psicosis de la epilepsia tipo esquizofrenia. CONFLICTO DE INTERESES: Ninguno. ABSTRACT: We describe the case of a 72 year old man with a diagnosis of temporal lobe epi-lepsy and paranoid schizophrenia, who presented atypical psychotic episodes which did not res-pond to anti-psychotic medication. His personali-ty had not deteriorated and he showed good social adjustment and functioning. After reviewing the case, we challenged the diagnosis of paranoid schizophrenia, proposing an alternative diagno-sis of temporal lobe epilepsy with ictal psycho-sis. He was successfully treated and discharged home. We review the literature on the subject. The psychosis of epilepsy are a diagnostic option which must be seriously considered in cases of treatment resistant atypical psychosis in subjects with good pre-morbid functioning and social ad-justment free from personality decline. KEY WORDS: temporal lobe epilepsy; ictal psychosis; psychosis of epilepsy; schizophrenia like psychosis of epilepsy. DECLARATION OF INTEREST: None.
Dataset: del re et al. 2015
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ABSTRACT: The clinical high risk (CHR) period is a phase denoting a risk for overt psychosis during which subacute symptoms often appear, and cognitive functions may deteriorate. To compare biological indices during this phase with those during first episode schizophrenia, we cross-sectionally examined sex- and age-matched clinical high risk (CHR, n=21), first episode schizophrenia patients (FESZ, n=20) and matched healthy controls (HC, n=25) on oddball and novelty paradigms and assessed the N100, P200, P3a and P3b as indices of perceptual, attentional and working memory processes. To our knowledge, this is the only such comparison using all of these event-related potentials (ERPs) in two paradigms. We hypothesized that the ERPs would differentiate between the three groups and allow prediction of a diagnostic group. The majority of ERPs were significantly affected in CHR and FESZ compared with controls, with similar effect sizes. Nonetheless, in logistic regression, only the P3a and N100 distinguished CHR and FESZ from healthy controls, suggesting that ERPs not associated with an overt task might be more sensitive to prediction of group membership. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.Psychiatry Research Neuroimaging 11/2014; 231(2). DOI:10.1016/j.pscychresns.2014.11.012 · 2.83 Impact Factor